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偏头痛慢性化期间多感官整合大脑区域的损伤:与前庭功能障碍的相关性

Liang Dong¹, Xiaoping Fan², Yulan Fan¹

¹Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Frontiers in molecular neuroscience

|July 19, 2023

概括

慢性偏头痛患者表现出与前庭功能障碍相关的大脑功能障碍. 改变的大脑连接可以预测偏头痛的频率和头的严重程度,这表明偏头痛相关的前体问题的潜在治疗点.

科学领域:

神经科学是一个神经科学.
神经学神经学
医疗成像医学成像

背景情况:

偏头痛经常伴随着前庭功能障碍,特别是在慢性偏头痛 (CM) 中.
连接偏头痛慢性化与前体问题的潜在机制仍然不清楚.
这项研究探讨了与偏头痛前庭功能障碍相关的大脑结构和功能变化.

研究的目的:

在慢性偏头痛 (CM) 患者中调查大脑功能障碍.
为了确定这些障碍是否与前庭功能障碍相关.
为了确定潜在的神经成像生物标志物与偏头痛相关的前庭问题.

主要方法:

使用磁共振成像 (MRI) 包括基于voxel的形态测量 (VBM) 来进行灰色物质体积 (GMV) 分析.
使用低频波动的平均幅度 (mALFF) 评估功能障碍.
通过多重线性回归检查了静止状态功能连接 (rsFC) 和与临床数据相关的神经成像发现.

主要成果:

在mALFF中观察到的群体差异包括超边缘回环 (SMG) 和角回环 (AG) 在内的区域.
慢性偏头痛 (CM) 患者与偶发性偏头痛 (EM) 和健康对照者 (HCs) 相比,左上顶顶回 (SPG) 和左中回 (MOG) 之间的rsFC增强.
SPG-MOG的rsFC预测了头障碍清单 (DHI) 的得分,SPG-MOG和右 SMG的rsFC预测了偏头痛的频率.

结论:

在偏头痛慢性化中的功能性大脑损伤集中在多感官集成区域.
SPG和MOG之间的rsFC是偏头痛频率和前庭功能障碍严重程度的重要预测因素.
识别的神经成像特征代表了在偏头痛中管理前庭功能障碍的潜在治疗点.

关键词:

编辑编辑编辑编辑编辑功能连接性的功能连接性偏头痛偏头痛偏头痛偏头痛多感应集成的多感应集成静止状态功能磁共振功能的静止状态功能磁共振.前体功能障碍是什么?前体功能障碍是什么?

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