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结晶体的简要历史:争议的起源
Jaime Fernández-Sarmiento1, Carolina Casas-Certain2, Sarah Ferro-Jackaman1
1Department of Critical Care Medicine and Pediatrics, Universidad de La Sabana, Fundación Cardioinfantil-Instituto de Cardiología, Bogotá, Colombia.
Frontiers in pediatrics
|July 19, 2023
概括
静脉注射的水晶化物,如正常盐水 (NS) 和林格的乳酸盐是常见的,但有副作用. 它们的历史成分与现代配方有很大不同,引发了人们对患者治疗结果的担忧.
科学领域:
- 医学科学 医学科学 医学科学
- 生物化学 生物化学
- 临床医学 临床医学
背景情况:
- 一个多世纪以来,用水晶体进行液体复苏一直是医疗治疗的基石.
- 通常使用的晶体合物包括0.9%的正常盐水 (NS) 和林格的乳酸盐,在全球范围内用于重症监护机构.
- 最近出现了关于流体过载和晶化合物组成的担忧,促使人们重新评估它们的使用.
研究的目的:
- 提供关于常用静脉注射晶体的发展的历史概述.
- 检查从早期配方到当前标准的晶体构成的演变.
- 突出在临床实践中关于晶体体安全性和有效性的不断变化的观点.
主要方法:
- 历史医学文本和科学出版物的文献评论.
- 分析早期和当代晶体溶液的化学成分.
- 检查临床研究和观察数据,将晶类药物使用与患者的治疗结果联系起来.
主要成果:
- 早期的液体溶液与现代配方 (如0.9% NS) 有很大差异.
- 0.9%的NS具有酸性pH值和高化物度,被归类为不平衡的溶液.
- 0.9%的NS与微循环功能障碍,免疫并发症,急性损伤和较差的临床结果有关.
结论:
- 结晶体发展的历史背景对于理解它们的当前用途和局限性至关重要.
- 通常使用的晶物的组成,特别是0.9%的NS,引起了关于患者安全和疗效的重大担忧.
- 对平衡晶溶液的进一步研究是有必要的,以减轻传统配方所观察到的不良影响.
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