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结肠癌的免疫功能与相关的miRNA和基因有关

Lu Han^1,2, Shiyun Chen^1,2, Zhe Luan³

¹Department of Oncology, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, China.

Frontiers in immunology

|July 19, 2023

概括

微RNAs (miRNAs) 显著影响结肠癌.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
遗传学遗传学是一个

背景情况:

结肠癌涉及瘤细胞和免疫微环境之间的复杂相互作用.
微RNAs (miRNAs) 是关键的基因调节器,其调节失调与结肠癌的免疫调节有关.
研究miRNAs在塑造肠癌免疫微环境中的作用至关重要.

研究的目的:

识别结肠癌相关的调节免疫功能基因的miRNAs.
分析这些基因的预后,免疫透和瘤纯度作用.
在结肠癌中探索miRNA驱动的免疫微环境调制.

主要方法:

利用了174名结肠癌患者的数据.
使用卷积神经网络进行分析.
进行了生存分析和多种生物信息学工具.

主要成果:

由miRNA调节的基因与CD4记忆休息细胞,M2巨细胞和激活的巨细胞有显著的关联.
这些基因主要集中在细胞因子-细胞因子受体相互作用途径中.
确定了影响结肠癌免疫细胞群的关键miRNA-基因相互作用.

结论:

这项研究加深了对结肠癌机制和免疫微环境的理解.
已识别的miRNA及其向基因为新的治疗策略提供了潜力.
miRNA生物标志物可以改善结肠癌的诊断,预后和个性化治疗.

关键词:

结肠癌是什么意思结肠癌是什么意思免疫细胞是免疫细胞.免疫微观环境免疫微环境这是一个小RNARNA.预后预后预后

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相关概念视频

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...