患有thalassemia的患者的COVID-19抗体反应
Nidhi Kumari1, Sunil Gomber1, Pooja Dewan1
1Pediatrics, University College of Medical Sciences, Delhi, IND.
Cureus
|July 19, 2023
概括
患有输血依赖性沙拉西米亚 (TDT) 的患者经历了较轻的COVID-19并最初形成了强烈的IgG抗体反应. 然而,随着时间的推移,抗体水平显著下降,这表明需要接种疫苗.
科学领域:
- 血液学 血液学 血液学
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 冠状病毒疾病2019 (COVID-19) 对患有并发症的个人构成严重风险,包括像血病这样的血红蛋白病.
- 有限的数据存在于临床表现和免疫反应COVID-19在患有血病的患者.
研究的目的:
- 为了比较临床特征和免疫球蛋白G (IgG) 抗体对SARS-CoV-2的反应,在患有输血依赖性沙拉西米亚 (TDT) 患者和没有输血依赖性沙拉西米亚患者中.
- 研究TDT患者的COVID-19严重程度和IgG抗体标位之间的关联.
主要方法:
- 一项病例控制研究涉及30名TDT患者和30名非thalassemia对照,所有人都确诊了COVID-19.
- 感染后6周,12周和24周收集血清样本,以通过化学发光免疫测试来定量IgG抗体.
主要成果:
- 与对照组相比,TDT患者的症状COVID-19病例显著减少 (p=0.009).
- 中位IgG标位在6周是可比的,但在12周 (p=0.011) 和24周 (p=0.006) 的TDT患者中显着较低.
- 两组抗体标位随着时间的推移而下降,并且不受COVID-19严重程度或并发症的影响.
结论:
- 输血依赖的血病患者表现出较轻的COVID-19和初始可比的IgG抗体反应.
- 超过3-6个月的TDT患者的抗体标位下降凸显了COVID-19疫苗接种对于持续保护的关键需求.
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