炎症生物标志物的临床价值在确定COVID-19的严重程度
Gulacti Umut1, Lok Ugur2, Aydin Irfan1
1Adıyaman University Training and Research Hospital Department of Emergency Medicine Adıyaman Turkey.
Journal of acute medicine
|July 19, 2023
概括
中性细胞对淋巴细胞和血小板比率 (NLPR) 和全身炎症指数 (SII) 可以帮助识别严重的COVID-19病例. 这些炎症标志物在急诊室入院时显示严重和非严重患者之间的显著差异.
科学领域:
- 血液学 血液学 血液学
- 传染性疾病 传染性疾病
- 关键护理医学 关键护理医学
背景情况:
- COVID-19的严重程度从轻度到严重的范围.
- 严重的COVID-19疾病的预测因素需要进一步阐明.
- 炎症标志物可能表明疾病进展.
研究的目的:
- 评估特定炎症指数在确定COVID-19严重性的作用.
- 评估系统性炎症指数 (SII),血小板与淋巴细胞比率 (PLR),血小板平均体积 (MPV),血小板平均体积与血小板比率 (MPR) 以及中性粒细胞与淋巴细胞和血小板比率 (NLPR) 的诊断性能.
主要方法:
- 对397名进入急诊室的COVID-19患者进行了回顾性研究.
- 根据世卫组织标准分类为严重或不严重的患者.
- 群体之间的人口,临床和炎症参数的比较.
- 对炎症生物标志物的接收器操作特征 (ROC) 曲线分析.
主要成果:
- 在严重的COVID-19患者中,NLPR,SII,MPR和PLR显著升高 (分别p < 0.0001,p = 0.0002,p = 0.0441,p = 0.0469).
- 在MPV中,严重程度组之间没有显著差异.
- NLPR显示出最高的AUC (0.705) 与最佳的灵敏度 (56.25%) 和特异性 (81.45%).
- SII显示了第二高的AUC (0.670) 与高特异性 (63.21%) 和灵敏性 (66.67%).
结论:
- NLPR和SII显示出作为新型炎症标志物的潜力,用于早期识别严重的COVID-19.
- 这些标记可以帮助在急诊室入院时对风险分层进行分层.
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