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在小鼠下中神经元反应与振幅调制声音的行为检测相关

Maurits M van den Berg¹, Esmée Busscher¹, J Gerard G Borst¹

¹Department of Neuroscience, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

Journal of neurophysiology

|July 19, 2023

概括

小鼠能够很好地检测高频振幅调制 (AM),但在低频率时却很难. 在下层结核中的神经活动,特别是发射速率的变化,解释了这种AM检测行为.

科学领域:

神经科学是一个神经科学.
听觉感知是一种听觉感知.
动物行为动物行为

背景情况:

广度调制 (AM) 在自然声音中至关重要,如语音和动物发声.
了解AM检测值和神经元编码对于听觉处理研究至关重要.

研究的目的:

为了确定在小鼠中的振幅调制 (AM) 检测值.
为了研究AM在下层结核 (IC) 中的底层神经元编码.

主要方法:

操作条件 (Go-NoGo任务) 用于训练小鼠进行AM检测.
在体内多电极电生理学记录了小鼠IC中的神经元活动.
人口响应建模结合了缩小维度与值检测.

主要成果:

小鼠对高AM频率 (高达512Hz) 的检测能力很好,但对低频率的检测能力很差.
在IC中,很少有单个神经元表现出强烈的512 Hz AM相锁定,不足以完全解释行为表现.
使用具有显著火速变化的神经元的人口模型准确预测了行为AM检测特征.

结论:

这项研究揭示了小鼠AM检测中的带通特征,在更高频率下具有优越的性能.
神经元活动,特别是IC神经元的一个子集的火速变化,是行为AM检测的关键.
这些发现提供了对听觉调制处理的神经机制的见解.

关键词:

幅度调制调制的幅度调制.在体内生电生理学.下一篇: 下一篇: 下一篇: 下一篇: 下一篇: 下一篇: 下一篇: 下一篇: 下一篇: 下一篇这里是鼠标鼠标鼠标鼠标鼠标鼠标.信号检测理论信号检测理论

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Hearing

Hearing

When we hear a sound, our nervous system is detecting sound waves—pressure waves of mechanical energy traveling through a medium. The frequency of the wave is perceived as pitch, while the amplitude is perceived as loudness.

The Cochlea

The Cochlea

The cochlea is a coiled structure in the inner ear that contains hair cells—the sensory receptors of the auditory system. Sound waves are transmitted to the cochlea by small bones attached to the eardrum called the ossicles, which vibrate the oval window that leads to the inner ear. This causes fluid in the chambers of the cochlea to move, vibrating the basilar membrane.