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Updated: Jul 23, 2025

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

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在散装和剂量形式Ixabepilone (瘤学药物) 的HPLC方法的开发:杂质的量化和强迫降解研究研究

Arjuna R Nekkalapudi1,2, Srinivasu Navuluri1, Sreenivas Pippalla3

  • 1Department of Chemistry, School of Applied Science & Humanities, Vignan's Foundation for Science, Technology and Research University (VFSTR), Guntur, Andhra Pradesh 522213, India.

Journal of chromatographic science
|July 19, 2023
PubMed
概括

一种新的高性能液态染色学 (HPLC) 方法准确量化药物配方中的艾克萨贝皮隆杂质和降解产品. 这种经过验证的方法确保了ixabepilone散装和注射形式的质量和安全性.

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相关概念视频

High-Performance Liquid Chromatography: Elution Process01:05

High-Performance Liquid Chromatography: Elution Process

In High-Performance Liquid Chromatography (HPLC), the elution process is critical to the separation of analytes and the quality of chromatographic results. Elution describes how compounds move through the column and separate based on their interactions with the mobile and stationary phases. This process determines the resolution, peak shape, and retention times in the chromatogram, which are essential for identifying and quantifying components in complex mixtures. Understanding the elution...
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High-Performance Liquid Chromatography: Instrumentation00:57

High-Performance Liquid Chromatography: Instrumentation

High-performance liquid chromatography, or HPLC, is an analytical technique that separates liquid samples under high pressures. An HPLC instrument consists of glass bottles for storing solvents called mobile phase reservoirs. HPLC-grade solvents are used to maintain high purity, and the dissolved gases are removed using a degasser, such as a vacuum pumping system or sparging with helium. The solvents are then pumped into the analytical column using a screw-driven syringe or reciprocating pumps.
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High-Performance Liquid Chromatography: Introduction

High-performance liquid chromatography(HPLC), formerly referred to as High-pressure liquid chromatography, is a powerful technique used to separate, identify, and quantify components in complex mixtures. The term "high pressure" refers to using high pressure to push the liquid mobile phase through the tightly packed columns.
In HPLC, two phases play a critical role in the separation process:
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