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新生儿的沃尔夫-帕金森-怀特模式:来自大型基于人口的队列研究的结果
Maria Munk Pærregaard1, Joachim Hartmann1, Anne-Sophie Sillesen1
1Department of Cardiology, Herlev-Gentofte Hospital, Copenhagen University Hospital, Borgmester Ib Juuls Vej 1, DK-2730 Herlev, Copenhagen, Denmark.
概括
沃尔夫-帕金森-白 (WPW) 模式发生在0.1%的新生儿中,主要是男孩. 大多数病例在童年早期就会消失,这表明有良性自然史.
科学领域:
- 儿童心脏病学 儿童心脏病学
- 电子生理学 电子生理学
- 新生儿健康 新生儿健康
背景情况:
- 沃尔夫 - 帕金森 - 怀特 (WPW) 综合征涉及附加电路,可能导致心室上动脉 (SVT) 和心脏突然死亡.
- WPW可以单独发生或与结构性心脏病一起发生.
研究的目的:
- 确定WPW模式在一个大,未经选择的新生儿队列中的流行率.
- 描述心电学和心声学特征.
- 在童年早期评估自然历史.
主要方法:
- 新生儿 (0-30天) 的前性,基于人口的队列研究.
- 电脑心电图和回声心电图分析.
- 匹配WPW病例 (n=17) 1:4与17489名新生儿的对照.
- 使用的辅助路径本地化算法.
主要成果:
- WPW模式的患病率为0.1% (17/17,489名新生儿),在男孩中更常见.
- 一名新生儿出现了额头肌吐;其他心声回声图与对照组相似.
- 附带路径主要是左侧的.
- 在平均年龄3.2岁时,WPW模式在4/14名儿童中持续存在;没有发生SVT发作.
结论:
- WPW模式在新生儿中很少见 (0.1%),通常与结构性心脏病无关.
- 观察到主要是左侧的辅助路径.
- 大多数病例在童年早期就会消失,这表明间歇性或正常化.
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