白物质完整性和慢性中风后上肢功能:一个ENIGMA中风恢复分析
Martin Domin1, Brenton Hordacre2, Pavel Hok1
1Functional Imaging Unit, Diagnostic and Neuroradiology, University Hospital Greifswald, Germany (M.D., P.H., M.L.).
Stroke
|July 19, 2023
概括
在中风后,严重的皮质脊柱管 (CST) 损伤需要依赖其他大脑途径来恢复上肢运动功能. 当CST受到损害时,剩余通道对于更好的运动结果至关重要.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 康复医学 康复医学 康复医学
背景情况:
- 皮质脊髓管 (CST) 是中风后上肢运动功能的关键生物标志物.
- 中枢神经系统的结构损伤可能需要其他白质管道的补偿作用,以恢复功能.
研究的目的:
- 为了研究替代白质道对上肢运动功能的相关性,慢性中风幸存者有不同程度的CST损伤.
- 为了确定残留途径是否补偿中风恢复中的CST完整性.
主要方法:
- 使用了ENIGMA中风恢复数据集 (n=166) 慢性中风患者的上肢损伤.
- 量化白质完整性使用CST,上纵束和状纤维的微分异型 (FA).
- 使用Fugl-Meyer上肢尺度,与上肢运动功能相关联的FA值.
主要成果:
- 在严重的中枢神经系统损伤的个体中,状纤维 (r=0.49,P=0.025) 和上纵 (r=0.51,P=0.018) 中较高的FA与更好的运动功能相关.
- 在不太严重的CST损伤的个体中没有发现任何显著的关联.
结论:
- 脑卒中幸存者有显著的CST损伤依赖于完整的替代途径来恢复运动功能.
- 剩余的白质道在严重的CST损伤后获得更好的上肢结果方面发挥了补偿作用.
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