基于SEER数据库的nomogram预测了IIIB期非小细胞肺癌患者的整体存活率
Ziye Li1,2, Pingfan Shi1,2, Chenge Qin1,2,3
1Integrated Chinese and Western Medicine Pulmonary Nodules Center, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
The clinical respiratory journal
|July 19, 2023
概括
这项研究开发了一种新工具,用于预测IIIB期非小细胞肺癌 (NSCLC) 患者的生存率. 经过验证的名录图使用9个因素进行个性化风险评估,有助于对NSCLC的治疗决定.
科学领域:
- 在瘤学瘤学.
- 医学统计 医学统计
- 公共卫生 公共卫生
背景情况:
- 阶段IIIB非小细胞肺癌 (NSCLC) 由于其晚期,在治疗规划中提出了重大挑战.
- 准确的预后工具对于有效的患者管理和NSCLC生存预测至关重要.
研究的目的:
- 在IIIB期NSCLC患者中评估各种因素的预后价值.
- 开发和验证一个名谱来预测这一患者群体的整体存活率 (OS).
主要方法:
- 利用了来自监测,流行病学和最终结果 (SEER) 数据库 (1975-2018) 的4323名IIIB期NSCLC患者的数据.
- 构建了一个包含预后因素的名图,包括年龄,种族,性别,主要部位,病理,T阶段和治疗方式 (手术,放射治疗,化疗).
- 通过使用C指数,校准曲线,ROC曲线,决策曲线分析 (DCA) 和临床影响曲线 (CIC) 评估诺莫格拉姆表现.
主要成果:
- 该名录集成了IIIB期NSCLC的九个关键预后因素.
- 取得了良好的歧视,C指数为0.672 (培训) 和0.675 (验证).
- 患者成功地被分为低风险和高风险群体,基于诺莫格拉姆分数.
结论:
- 开发了第一个经过验证的名谱来估计IIIB期NSCLC患者的整体存活率.
- 该名图提供了个性化的3年和5年的OS风险估计.
- 该工具可以帮助临床医生对IIIB期NSCLC进行个性化风险评估和治疗策略.
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