关于基于叶酸的高分子凝作为向治疗剂的能力的见解
Carla Rizzo1, Patrizia Cancemi2, Miriam Buttacavoli2
1Università degli Studi di Palermo, Dipartimento STEBICEF, Sezione di Chimica, Viale delle Scienze Ed. 17, 90128 Palermo, Italy. francesca.danna@unipa.it.
Journal of materials chemistry. B
|July 19, 2023
概括
基于叶酸的新型有机盐显示出作为向化疗剂的前景. 这些化合物在溶液和凝阶段对癌细胞具有选择性的抗增殖活性.
科学领域:
- 超分子化学 超分子化学
- 材料科学 材料科学 材料科学
- 癌症治疗方法 癌症治疗方法
背景情况:
- 开发向化疗剂对于有效的癌症治疗至关重要.
- 叶酸受体在各种癌细胞上过度表达,使它们成为药物输送的有吸引力的目标.
- 有机盐为潜在的治疗应用提供可调节的特性.
研究的目的:
- 为了合成和表征新的伊米达和基叶酸盐.
- 研究这些盐的光物理性质,自我组装行为和凝能力.
- 评估合成盐对乳腺癌细胞系的抗增殖活性和作用机制.
主要方法:
- 基于叶酸的有机盐的合成.
- 紫外线和光光谱学用于光物理研究.
- 动态光散射 (DLS) 和整体和凝特征学.
- 对MDA-MB-231,MCF-7和h-TER T-RPE-1细胞系的抗增殖活性进行MTT测定.
- 二二二二甲酸盐测试以评估氧化应激.
主要成果:
- 合成的叶酸盐表现出有趣的光物理特性,并形成聚合物.
- 这些盐在生物相容溶剂中表现出凝能力,形成稳定的软材料.
- 对表达叶酸受体的癌细胞 (MDA-MB-231,MCF-7) 观察到抗增殖活性,对正常细胞有选择性 (h-TER T-RPE-1).
- 这些化合物在凝阶段保留了生物活性,表明了持续药物递送的潜力.
结论:
- 叶酸基有机盐可以作为向化疗剂.
- 疗效和选择性取决于癌细胞系和特定的盐结构.
- 这些材料显示出开发用于癌症治疗的新型药物输送系统的潜力.
更多相关视频
05:24Author Spotlight: Improving the Production of Self-Assembling Fibers and Peptide Hydrogels for Superior Biocompatibility
Published on: September 6, 2024
1.2K
08:39Magnetic and Thermal-sensitive PolyN-isopropylacrylamide-based Microgels for Magnetically Triggered Controlled Release
Published on: July 4, 2017
9.0K
相关概念视频
02:57Targeted Cancer Therapies
7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.7K
01:26Targets for Drug Action: Overview
6.4K
Drugs target macromolecules to modify ongoing cellular processes. Primary drug targets include receptors, ion channels, transporters, and enzymes.
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...
6.4K