在SARS-CoV-2德尔塔和奥米克朗波期间短期暴露于环境空气污染和COVID-19严重程度:一项多中心研究
Barbara Poniedziałek1, Piotr Rzymski1,2, Dorota Zarębska-Michaluk3
1Department of Environmental Medicine, Poznan University of Medical Sciences, Poznań, Poland.
Journal of medical virology
|July 19, 2023
概括
对空气污染物如PM10,PM2.5和烯 (B) 的短期暴露与严重的COVID-19结果有关. 这包括症状增加,高炎症,凝血病,住院患者的死亡率更高.
科学领域:
- 环境健康 环境健康
- 传染性疾病 传染性疾病
- 呼吸系统医学 呼吸系统医学
背景情况:
- 空气污染是已知的呼吸道疾病的风险因素.
- 空气污染物对COVID-19严重程度和结果的影响需要进一步调查.
- 颗粒物 (PM) 和烯 (B) 是具有潜在健康影响的关键空气污染物.
研究的目的:
- 评估短期暴露于PM10,PM2.5和B(a) P与COVID-19的临床过程之间的关联.
- 分析不同SARS-CoV-2流行浪潮 (三角形和Omicron变种) 期间的这些关联.
- 确定空气污染物暴露与COVID-19症状,高炎症,凝血病和患者结果之间的关系.
主要方法:
- 两次大流行期间住院的COVID-19患者的回顾性分析.
- 在入院前一周评估PM10,PM2.5和B(a) P的24小时平均水平.
- 根据患者人口统计 (年龄,BMI,性别) 和并发症的统计调整.
主要成果:
- 超过限值的B (a) P暴露与发烧增加,疲劳,超炎症 (高CRP,IL-6),凝血病 (高d-二次数) 和致命结果相关.
- 升高的PM10和PM2.5水平与呼吸系统症状,高甲,低氧和,需要氧气支持和死亡有关.
- 无论变种的致病性如何,在三角形和Omicron变种浪潮期间都观察到显著的关联.
结论:
- 在住院患者中,短期暴露于升高的PM和B(a) P水平会加剧COVID-19的严重程度.
- 空气污染有助于COVID-19的整体健康负担,影响了不同SARS-CoV-2变种的结果.
- 针对空气质量的公共卫生策略可能会减轻呼吸道流行病的影响.
相关概念视频
Asthma-I: Introduction
2.7K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
2.7K
Chronic Obstructive Pulmonary Disease-II: Pathophysiology
2.9K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
2.9K
COPD: Pathogenesis and Clinical Features
354
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
354
Transmission-based Precautions II: Airborne and Protective Environment
1.3K
Transmission-based precautions are for patients infected or suspected to be infected (or colonized) with organisms posing a significant risk to others. The transmission precautions include airborne and protective environment precautions.
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
1.3K
Chronic Obstructive Pulmonary Disease-I: Introduction
2.8K
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
2.8K
COPD: Management Using Bronchodilators and Corticosteroids
249
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
249


