在视觉雪综合征和偏头痛与光环中的异常谷氨酸和血清能连接性
Francesca Puledda1,2, Ottavia Dipasquale2, Benjamin J M Gooddy3
1Headache Group, Wolfson SPaRRC, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Annals of neurology
|July 19, 2023
概括
视觉雪综合征 (VSS) 涉及改变的大脑连接. 在VSS患者中发现了谷氨酸和血清素系统的变化,其中一些变化类似于带有光环的偏头痛,表明共享的神经生物学机制.
科学领域:
- 神经科学是一个神经科学.
- 神经成像是一种神经成像.
- 神经药理学神经药理学
背景情况:
- 视觉雪综合征 (VSS) 是一种神经疾病,神经药理学基础不明.
- 确定神经递质参与对于理解VSS病理生理学至关重要.
研究的目的:
- 通过功能磁共振成像 (fMRI) 和受体目标地图来研究VSS的神经药理学变化.
- 为了确定特定的神经递质系统调节大脑电路在VSS.
主要方法:
- 采用了受体丰富功能连接对象分析 (REACT).
- 对包括谷氨酸,血清素和特定受体 (GABA-A,NMDA,5HT1B,5HT2A) 在内的神经递质系统进行了功能连接 (FC) 估计.
- 在VSS患者,健康对照 (HCs) 和偏头痛患者 (MIG) 之间比较了FC地图.
主要成果:
- 与HC和MIG相比,VSS患者在前带状皮质 (ACC) 中表现出减少的谷氨基质网络FC,与HC和MIG相比.
- 在VSS患者的胰岛,极和轨道前皮层中观察到降低的血清活力网络FC,类似于带有光环 (MwA) 的偏头痛.
- 在VSS中发现了富含5HT2A的网络中减少的FC,主要是在occipito-temporo-parietal协会皮层中.
结论:
- 谷氨酸和血清素的改变有助于在视觉,突出和边缘系统内的VSS中的大脑连接性变化.
- 在VSS中改变的血清连接性独立于偏头痛,但与MwaA相比,表明共享的神经生物学.
- 这些发现为VSS的神经生物学基础及其与偏头痛的关系提供了洞察力.
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