克里普托科科西斯:关于抗真菌耐药性的文献叙事综述
Maria Ismênia T Kakizaki1, Marcia DE S C Melhem2,3
1Instituto de Assistência Médica ao Servidor Público Estadual: Iamspe, Setor de Oncologia e Hematologia, Rua Pedro de Toledo, 1800, Vila Clementino, 04039-901 São Paulo, SP, Brazil.
Anais da Academia Brasileira de Ciencias
|July 19, 2023
概括
加密球菌的抗真菌耐药性是一个越来越令人担忧的问题,沃里科纳对*Cryptococcus neoformans*显示较高的最小抑制度 (MIC). 需要更多的研究才能充分了解抵抗率.
科学领域:
- 菌类学 菌类学是指菌类学.
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 由于高发病率和死亡率,加密球菌病症对公共卫生构成重大威胁.
- 即使使用抗真菌疗法,也观察到临床耐药性和治疗失败.
- 在艾滋病患者中长时间使用三醇可能会导致*Cryptococcus*物种的抗真菌耐药性.
研究的目的:
- 进行叙述性文献审查,对导致加密球菌病的病原体的抗真菌耐药性进行研究.
- 分析用于加密球菌病管理的抗真菌药物的最小抑制度 (MIC) 数据.
主要方法:
- 从2010年到2022年的出版物进行叙事审查.
- 使用谷歌学者和Scopus进行的文献搜索.
- 从选定的研究中分析最低抑制度 (MIC) 值.
主要成果:
- 审查发现了沃里科纳的MIC值较高,特别是对*Cryptococcus neoformans*.
- 数据表明,加密球菌病原体的抗真菌耐药性增加的趋势.
结论:
- 有一个显著的缺乏统计分析的数据对抗菌耐药率的密码球菌病原体.
- 为了准确评估地理和时间阻力模式,需要进行进一步的研究,并进行强有力的统计分析.
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