在克罗恩病患者中,与低骨肌肉指数相关的因素
Jiehua Zhi1, Bing Jiāo1, Shan Qing2
1Yangzhou University, The Affiliated Hospital of Yangzhou University, Department of Gastroenterology - Yangzhou, China.
Revista da Associacao Medica Brasileira (1992)
|July 19, 2023
概括
骨肌肉损失在克罗恩病中很常见,导致残疾. 年龄,女性性别和疾病活动等因素影响肌肉质量,表明营养状况和粘膜愈合是关键的管理目标.
科学领域:
- 胃肠病学 胃肠病学
- 肌肉骨健康 肌肉骨健康
- 医疗成像医学成像
背景情况:
- 克罗恩氏病经常导致骨肌肉损失,导致患者的残疾.
- 识别与肌肉损失相关的因素对于开发干预措施至关重要,以预防克罗恩病患者的与肉类相关的残疾.
研究的目的:
- 在克罗恩病患者中确定与骨肌肉损失相关的因素.
- 确定潜在的管理目标,以预防这种人群中与肉症相关的残疾.
主要方法:
- 克罗恩病患者根据从腹部CT扫描中得出的L3骨肌指数被分为低和正常的骨肌群.
- 临床,实验室和结肠镜参数在各组之间进行了比较.
- 使用单变量和多变量逻辑回归模型来确定克罗恩病相关肌肉损失的预后标志物.
主要成果:
- 在191名克罗恩病患者中,有116人 (60.73%) 呈现低L3骨肌指数.
- 多变量分析显示了肌肉损失与年龄,女性性别,疾病持续时间,内镜疾病活性 (克罗恩病简单内镜评分),血清白蛋白和血清肌素之间的关联.
- 对于每个相关因素,报告了特定的几率比率 (OR) 和置信区间 (CI).
结论:
- 虽然性别,年龄和疾病持续时间是克罗恩病中肌肉损失的不可控制因素,但专注于粘膜愈合和改善营养状况的治疗策略可能是有益的.
- 这些干预措施可以在克罗恩病患者中保持肌肉质量方面发挥至关重要的作用.
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