血管内皮生长因子基因插入/删除多态性与土耳其冠状病毒病患者的维生素D水平有关2019年冠状病毒病患者
Serbulent Yigit1,2, Sengul Tural3, Recai Aci4
1Ondokuz Mayis University, Faculty of Veterinary Medicine, Department of Genetics - Samsun, Turkey.
概括
血管内皮生长因子 (VEGF) DD基因型和D等位基因与土耳其COVID-19患者的维生素D水平有关. 这一发现表明,与疾病严重程度和维生素D状况存在潜在的遗传关联.
科学领域:
- 遗传学 是一个遗传学.
- 分子生物学分子生物学
- 传染性疾病 传染性疾病
背景情况:
- 冠状病毒疾病2019 (COVID-19),由SARS-CoV-2引起,是一种影响血管健康的系统性疾病.
- 内皮损伤和血管炎症是COVID-19的关键病理特征.
- 遗传因素可能会影响COVID-19患者的个体易感性和疾病呈现.
研究的目的:
- 在土耳其人口中调查血管内皮生长因子 (VEGF) 基因插入/删除多态和COVID-19之间的关联.
- 为了确定特定的VEGF基因型是否与COVID-19患者的疾病状况或严重程度标志物相关.
主要方法:
- 一项涉及179名参与者的病例控制研究:79名COVID-19患者和来自土耳其人口的100名健康对照.
- 从所有参与者的外周血液样本中分离出DNA.
- 用聚合酶连锁反应 (PCR) 分析来基因型化VEGF基因插入/删除多态.
主要成果:
- 在对照组中,VEGF基因的DD基因型和D等位基因与高维生素D水平具有统计学意义的关联 (DD基因型p=0.005,D等位基因p=0.006).
- 在比较II+ID基因型与DD基因型时,在高维生素D控制组 (p=0.007) 中观察到显著差异.
结论:
- 血管内皮生长因子基因的DD基因型和D等位基因与2019年新冠肺炎诊断的土耳其患者的维生素D水平有关.
- 这些发现表明,在研究人口中,在COVID-19的背景下,可能存在与VEGF多态和维生素D状态相关的潜在遗传倾向.
相关概念视频
Connective Tissue Cell Types
3.3K
Connective tissue develops from the mesoderm of a developing embryo and consists of cells, fibers, and ground substance: a gel-like material containing large complexes of carbohydrates and proteins. Connective tissue was first identified as a separate tissue family in the 18th century, and Johannes Peter Muller coined the term connective tissue.
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
3.3K
Single Nucleotide Polymorphisms-SNPs
15.3K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
15.3K
Role of Skin in Vitamin D Synthesis
5.3K
The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
5.3K
Vitamins
783
Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced...
783
Role of Vitamins in Maintaining Bone Health
3.4K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
3.4K
Regulation of Angiogenesis and Blood Supply
2.6K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.6K


