相关实验视频

Updated: Jul 23, 2025

Flow Cytometry-based Drug Screening System for the Identification of Small Molecules That Promote Cellular Differentiation of Glioblastoma Stem Cells

Flow Cytometry-based Drug Screening System for the Identification of Small Molecules That Promote Cellular Differentiation of Glioblastoma Stem Cells

Published on: January 10, 2018

向TRIM24促进神经母细胞瘤的分化,并通过LSD1/CoREST复合体降低瘤性

Qiqi Shi¹, Bo Yu¹, Yingwen Zhang¹

¹Renji-Med X Clinical Stem Cell Research Center, Ren Ji Hospital, Shanghai Cancer Institute, School of Medicine, State Key Laboratory of Systems Medicine for Cancer, Shanghai Jiao Tong University, Shanghai, 200127, China.

Cellular oncology (Dordrecht, Netherlands)

|July 19, 2023

概括

TRIM24被确定为神经母细胞瘤 (NB) 差异化的关键调节者. 针对TRIM24与视网氨酸协同增强NB分化并减少瘤生长.

科学领域:

在瘤学瘤学.
发展生物学发展生物学
分子生物学分子生物学

背景情况:

高危神经母细胞瘤 (NB) 是一个严重的临床挑战,预后不佳.
诱导NB分化提供了一个潜在的治疗策略,但潜在的机制仍然不清楚.

研究的目的:

为了确定神经母细胞瘤分化的关键调节者.
研究TRIM24在NB分化中的作用及其治疗潜力.

主要方法:

对多个数据集和临床标本的分析.
评估TRIM24对NB分化和生长的影响,使用细胞检测和异种移植.
RNA-Seq,qRT-PCR,质谱和共免疫沉以阐明机制.

主要成果:

TRIM24在NB中表达很高,并与差异化和预后相关.
TRIM24淘汰赛促进NB细胞分化,减少干细胞,并抑制瘤生长.
TRIM24通过影响LSD1/CoREST复合体和激活视网膜酸通路来调节神经分化通路.

结论:

TRIM24对于调节NB分化至关重要.
TRIM24代表了一个有前途的治疗标,特别是在NB差异化疗法中与网膜酸结合使用时.

关键词:

不同化的差异化一个LSD1一个LSD1 神经母细胞瘤是一种神经母细胞瘤.雷蒂诺酸是什么意思雷蒂诺酸是什么意思在 TRIM24 中,

更多相关视频

Isolation, Enrichment, and Maintenance of Medulloblastoma Stem Cells

Isolation, Enrichment, and Maintenance of Medulloblastoma Stem Cells

Published on: September 1, 2010

Transposon Mediated Integration of Plasmid DNA into the Subventricular Zone of Neonatal Mice to Generate Novel Models of Glioblastoma

Transposon Mediated Integration of Plasmid DNA into the Subventricular Zone of Neonatal Mice to Generate Novel Models of Glioblastoma

Published on: February 22, 2015

相关概念视频

Abnormal Proliferation

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...