产前大麻素暴露对胎盘的影响和呼吸神经回路的发展
Daniela Cáceres1, Martín Ochoa1, Marcelo González-Ortiz2
1Laboratorio de Sistemas Neurales, Departamento de Biología, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago, Chile.
Advances in experimental medicine and biology
|July 19, 2023
概括
怀孕期间使用大麻可能会影响胎儿的发育,特别是呼吸系统. 本综述研究了产前大麻素暴露对胎盘功能和神经发育的影响.
科学领域:
- 产科和妇科 产科和妇科
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
背景情况:
- 怀孕期间使用大麻的数量正在增加,尽管人们对delta-9-tetrahydrocannabinol (THC) 的安全性和潜在的致死性影响存在担忧.
- 内激素系统,包括大麻素受体 (CB1r,CB2r) 和内源性配体,在胎儿发育中起着至关重要的作用,但其从产前大麻素暴露中产生的长期影响尚未完全理解.
- 动物模型表明产前大麻素暴露可以改变胎盘和胚胎胎的器官发育,可能影响神经和非神经组织.
结论:
- 了解产前大麻素暴露的影响对于评估胎儿发育的风险至关重要.
- 需要进一步的研究来阐明在怀孕期间使用大麻对后代的长期后果.
- 本次审查强调了对大麻在孕妇中具有致病性潜力的批判性评估的必要性.
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