肉症状况的变化预测了可切除食道癌患者的生存率
Uzair M Jogiat1, Vickie Baracos2, Simon R Turner1
1Division of Thoracic Surgery, Department of Surgery, University of Alberta, Edmonton, AB, Canada.
Annals of surgical oncology
|July 19, 2023
概括
在治疗期间 Sarcopenia 的发展预测食道癌症患者的生存率会更差. 随着时间的推移,肌肉损失与更高的复发风险有关,这凸显了其在治疗监测中的重要性.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 老年病的医生 老年病的医生
背景情况:
- 肉是食道癌患者生存的已知预测因素.
- 了解肉症的动态变化对于切除食道癌症的管理至关重要.
研究的目的:
- 为了研究如何改变萨尔科佩尼亚状态影响切除食道癌患者的生存结果.
- 分析萨科佩尼亚发育和进展与整体存活率 (OS) 和无病存活率 (DFS) 之间的关联.
主要方法:
- 对接受三种疗法治疗的食道癌症患者进行了回顾性队列研究.
- 身体组成,包括骨肌指数,使用计算机断层扫描 (CT) 在分期,后新辅助疗法和1年监测时进行评估.
- 总生存率 (OS) 和无疾病生存率 (DFS) 通过Kaplan-Meier,日志等级测试和多变量Cox比例危险模型进行了分析.
主要成果:
- 麻症的患病率从分期时的17.0%增加到新辅助疗法后的38.1%.
- 鉴定后新辅助治疗的萨尔科佩尼亚显著与更糟糕的OS (HR 2.65) 和DFS (HR 1.80) 相关.
- 骨肌指数的净损失与较差的OS (HR 0.93) 和DFS (HR 0.94) 有显著的关联.
结论:
- 在新辅助疗法期间,肉类的发展与食道癌患者中较差的DFS和OS有关.
- 随着时间的推移,净肌肉损失是早期疾病复发高风险的关键指标.
- 监测肉变化为食道癌管理提供了有价值的预后信息.
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