短暂的发烧发作是良性的吗? 一个系统的审查和叙事综合
Laura Gould1,2, Victoria Delavale1,2, Caitlin Plovnick3
1Comprehensive Epilepsy Center, NYU Langone Health, New York, New York, USA.
Epilepsia
|July 19, 2023
概括
儿童发烧发作通常是良性的,但很少与突然死亡有关. 关于长期结果的研究有限,一些研究表明,在特定情况下,死亡风险增加.
科学领域:
- 儿科神经学 儿科神经学
- 神经科学是一个神经科学.
- 流行病学 流行病学
背景情况:
- 发烧发作影响2%-5%的美国儿童,通常被认为是良性的.
- 有关和罕见的突然不明原因死亡的潜在联系存在担忧.
研究的目的:
- 为了比较简单和复杂发烧的儿童与对照儿童的死亡率,神经发育障碍和神经病理学.
- 系统地审查有关这些结果的现有文献.
主要方法:
- 对年龄在3-72个月的儿童发烧发作≤30分钟的研究进行系统审查.
- 搜索死亡率,神经发育和神经病理学的结果至2022年7月18日.
- 通过研究设计评估偏差风险和分层结果.
主要成果:
- 包括26项研究 (2665名患有发烧的儿童,1206名对照).
- 死亡率数据显示出对比:队列研究报告没有死亡,而死亡系列显示死亡率为24.1%.
- 神经发育问题往往早于发烧发作;在突然死亡中发现的海马体异常.
结论:
- 对简单或短暂复杂发烧后的结果的研究是有限的.
- 队列研究存在局限性 (样本大小,偏差,随访时间).
- 突发死亡登记表明,发烧可能会增加与发烧相关的死亡风险,这需要进一步进行长期前性研究.
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