与儿童多系统炎症综合征相关的神经和心理后果
Caitlin K Rollins1,2, Johanna Calderon1,3,4, David Wypij5,6,7
1Department of Neurology, Boston Children's Hospital, Boston, Massachusetts.
JAMA network open
|July 19, 2023
概括
患有多系统炎症综合征 (MIS-C) 的儿童在出院6-12个月后会经历持久的神经和心理影响,包括工作记忆障碍和生活质量下降.
科学领域:
- 儿科神经学 儿科神经学
- 传染病 传染病 传染病
- 儿童心理学 儿童心理学
背景情况:
- 儿童多系统炎症综合征 (MIS-C) 可能导致急性神经问题.
- 在MIS-C幸存者的长期神经,心理和认知后果没有得到充分的记录.
- 缺乏对离院6-12个月后认知功能的直接评估.
研究的目的:
- 描述MIS-C后儿童的神经,心理和生活质量的后果.
- 为了比较MIS-C患者与兄弟姐妹或社区对照者的结果.
主要方法:
- 美国和加拿大的横截面队列研究 (2020年11月至2021年11月).
- 远程神经检查和神经心理评估 (认知,行为,生活质量,日常功能).
- 用于组比较的概括估计方程.
主要成果:
- 与对照组 (n=44) 相比,MIS-C患者 (n=64) 的神经异常发生频率更高 (25%与7%相比).
- 在MIS-C组,工作记忆得分 (执行功能) 较低,在大多数其他认知指标上表现相似.
- 父母报告说,MIS-C幸存者的心理结果更差 (抑郁症,体质化) 和生活质量更差.
结论:
- 患有MIS-C的儿童在出院6-12个月后表现出持续的神经和心理缺陷.
- 发现包括神经学检查异常,工作记忆受损,体化/抑郁症增加,生活质量降低.
- 建议加强监测,以便早期检测和治疗这些后果.
相关概念视频
01:17Chronic Bowel Disorders: Introduction
489
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
489
01:30Inflammatory Bowel Disease II: Crohn's Disease
296
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
296
01:27Post-traumatic Stress Disorder
76
Post-traumatic stress disorder (PTSD) is a psychiatric condition that arises following exposure to traumatic events such as natural disasters, forced displacement, or severe accidents. It significantly impairs individuals' ability to cope with daily activities and disrupts their emotional and psychological equilibrium.
Symptoms and Behavioral Manifestations
A spectrum of distressing symptoms characterizes PTSD. Recurrent flashbacks, where individuals involuntarily relive traumatic events,...
Symptoms and Behavioral Manifestations
A spectrum of distressing symptoms characterizes PTSD. Recurrent flashbacks, where individuals involuntarily relive traumatic events,...
76
01:30Dissociative Identity Disorder
155
Dissociative Identity Disorder (DID), previously termed multiple personality disorder, is a complex psychological condition characterized by the presence of two or more distinct identities or personality states. Each identity exhibits unique patterns of behavior, voice, and mannerisms and may possess separate memories and emotional responses. The alternating control between identities can result in memory gaps and challenges in recalling daily activities, often exacerbating the individual's...
155