ангиотензин I-转化酶2型的表达在2型糖尿病捐赠者的胰腺小岛上增加
Daniela Fignani1,2, Erika Pedace1,2, Giada Licata1,2
1Diabetes and Metabolic Disease Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy.
Diabetes/metabolism research and reviews
|July 19, 2023
概括
在2型糖尿病 (T2D) 患者的胰腺β细胞中增加的 ангиотензинI转化酶2型 (ACE2) 表达可能会增加对SARS-CoV-2感染的易感性. 这一发现表明T2D,COVID-19严重程度和糖代谢控制之间的潜在联系.
科学领域:
- 内分泌学 在内分泌学.
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
背景情况:
- ангиотензин I转化酶2型 (ACE2) 受体对于SARS-CoV-2进入细胞至关重要,包括人类胰腺β细胞.
- 在SARS-CoV-2感染和糖尿病之间存在潜在的双向关系,病毒感染可能会引发新发糖尿病或恶化血糖控制.
- 糖尿病患者β细胞中ACE2表达的改变在很大程度上仍未得到研究.
研究的目的:
- 研究2型糖尿病 (T2D) 捐赠者的胰腺β细胞中ACE2的局部表达模式,与非糖尿病 (ND) 对照进行比较.
- 确定T2Dβ细胞中改变的ACE2表达是否可以解释对SARS-CoV-2感染的易感性增加.
主要方法:
- 从20个T2D和20个ND捐赠者的胰腺截面中对ACE2和胰岛素表达的免疫光分析.
- 在1082个胰腺小岛内对ACE2和胰岛素同位素的定量分析.
- 在序列截面上使用CD68免疫组织化学检测巨细胞.
主要成果:
- 在胰腺β细胞和微血管系统中证实了ACE2的表达.
- 与ND对照组相比,来自T2D捐赠者的胰腺小岛表现出明显更高的ACE2表达和ACE2-胰岛素同位素化.
- 在T2D胰腺中观察到CD68+巨细胞增加的趋势,与ACE2水平升高相关.
结论:
- 在T2D胰腺小岛中ACE2表达升高可能会增加对SARS-CoV-2感染的易感性.
- 这种增加的易感性可能会导致较差的糖代谢控制和COVID-19的T2D患者的疾病严重程度增加.
- 需要进一步的研究来探索这些发现对病毒流行期间糖尿病管理的影响.
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