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最近因C型肝炎病毒感染而接受治疗的人群中再感染的发生率和风险
Marianne Martinello1, Joanne M Carson1, Marc Van Der Valk2,3
1Kirby Institute, UNSW Sydney, Sydney, Australia.
AIDS (London, England)
|July 19, 2023
概括
肝炎C病毒 (HCV) 再感染在治疗后持续有风险行为的人群中很常见. 高发病率强调需要治疗后的监测和减少危害的策略,以支持消除HCV的努力.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 肝炎C病毒 (HCV) 再感染是实现HCV消除目标的重要障碍.
- 了解治疗后HCV再感染的发病率和风险因素对于开发有效的控制策略至关重要.
研究的目的:
- 评估最近HCV感染 (持续时间<12个月) 接受治疗的人群中C型肝炎病毒 (HCV) 再感染的发生率.
- 为了确定与该人群中HCV再感染相关的因素.
主要方法:
- 一个国际随机试验队列治疗最近的HCV被跟踪了长达2年.
- 用人时间计算了再感染发生率,并使用Cox回归分析了相关因素.
主要成果:
- 在196名患有再感染风险的参与者中,28例HCV再感染发生在198人年内,每100人年发生率为14.2.
- 与再感染相关的因素包括先前的HCV再感染,治疗后的注射药物使用,以及与偶然的男性伴侣进行无避孕套的交.
- 在同性恋和双性恋男性中,涉及注射后治疗的性化药物使用也是一个重要因素.
结论:
- 在持续有风险行为的人群中,高HCV再感染率需要强有力的治疗后监测.
- 迅速重新治疗和有针对性的降低危害策略对于预防复发性HCV感染和支持消除努力至关重要.
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