在患有非艾滋病定义癌症的患者中,根据艾滋病毒状况表观遗传年龄的差异
Brittney L Dickey1, Ryan M Putney2, Gita Suneja3
1Department of Cancer Epidemiology.
AIDS (London, England)
|July 19, 2023
概括
艾滋病毒感染者 (PWH) 呈现加速表观遗传衰老,与非艾滋病定义性癌症 (NADC) 的死亡风险增加有关. 这项研究强调了加速生物衰老作为PWH的NADC存活的重要因素.
科学领域:
- 生物医学研究的研究.
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 癌症流行病学癌症流行病学
背景情况:
- 艾滋病毒感染者 (PWH) 的寿命越来越长,导致非艾滋病定义癌症 (NADC) 的发病率增加.
- 表观遗传衰老生物标志物与癌症风险相关,但它们在PWH与NADC中的作用未得到充分研究.
- 癌症是PWH的主要死亡原因.
研究的目的:
- 为了研究与NADC的PWH和HIV未感染个体之间的表观遗传年龄差异.
- 确定表观遗传年龄加速与被诊断为NADC的PWH患者的生存结果之间的关联.
主要方法:
- 匹配的队列研究比较PWH和未感染HIV的个体.
- 使用Illumina甲基化EPIC BeadChip和三个表观遗传时钟 (Horvath,GrimAge,epiTOC2) 进行表观遗传年龄估计.
- 使用线性和考克斯回归模型分析年龄加速及其与生存的关联.
主要成果:
- 与非艾滋病毒感染的对照组相比,具有NADC的PWH表现出显著更高的生物年龄,根据epitoc2和GrimAge的估计.
- 生物衰老的加速,特别是GrimAge,在PWH中显著高,并且与死亡风险增加有关 (HR 1.11;95% CI 1.04-1.18).
- 在调整免疫细胞组成后,GrimAge加速仍然显著.
结论:
- 与NADC携带的PWH与未感染HIV的对应物相比,具有更高的表观遗传年龄.
- 加快的生物衰老与被诊断为NADC的PWH患者的生存结果较差显著相关.
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