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IL8在骨髓性恶性瘤中的作用

Nandini Ramachandra^1,2, Malini Gupta³, Leya Schwartz¹

¹Department of Oncology, Blood Cancer Institute, Montefiore Einstein Cancer Center, Bronx, NY, USA.

Leukemia & lymphoma

|July 19, 2023

概括

过度表达的INTERLEUKIN-8 (IL8) 通过激活瘤途径和抑制免疫反应,驱动髓状细胞癌. 抑制IL8-CXCR1 / 2通路显示这些血液恶性瘤的治疗有前途.

科学领域:

在瘤学瘤学.
血液学血液学血液学
免疫学免疫学免疫学

背景情况:

异常的介质素-8 (IL8) 过度表达与骨髓质综合征 (MDS),急性骨髓性白血病 (AML) 和骨髓增殖性新生体 (MPN) 有关.
IL8 (CXCL8),是一种由恶性细胞和瘤微环境分泌的化学激素,与CXCR1/CXCR2受体结合.
这种结合激活了瘤信号,并招募了髓质衍生抑制细胞,培养了免疫抑制瘤微环境.

研究的目的:

审查IL8信号通路在髓状瘤致病的关键作用.
讨论针对血液癌症中的IL8-CXCR1/2轴的治疗潜力.
探索IL8向治疗在骨髓瘤瘤中的未来方向.

主要方法:

关于IL8信号在髓状腺癌中的临床前和临床研究的文献综述.
对IL8影响白血病发生和瘤微环境的分子机制的分析.
对目前针对IL8通路的治疗策略的评估.

主要成果:

过度表达IL8/CXCR1/2与MDS和AML的预后不佳以及骨髓纤维化增加与骨髓纤维化相关.
临床前研究表明,抑制IL8/CXCR1/2可以抑制白血病干细胞的生长,并使瘤微环境正常化.
准IL8-CXCR1/2通路是一种有前途的治疗策略,目前正在临床研究中.

结论:

IL8信号通路是髓状细胞恶性瘤的关键驱动因素,有助于疾病进展和不良结果.
抑制IL8-CXCR1 / 2轴代表了髓状瘤瘤的可行的治疗策略.
目前正在进行的评估小分子抑制剂和单克隆抗体的临床试验为改善患者管理提供了希望.

关键词:

在AML,AML就是AML.它可以抑制IL8的抑制.白血病的干细胞是白血病干细胞.在 MDS MDS 中.在 MPN MPN MPN 的情况下.

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