环境PM2.5成分与骨强度有关:来自中国多民族研究的证据
Hongyu Yan1, Wenge Tang2, Lele Wang1
1West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
The Journal of clinical endocrinology and metabolism
|July 19, 2023
概括
长期暴露于细颗粒物 (PM2.5) 和其成分与骨强度降低有关. 酸盐暴露可能显著增加骨质疏松症和骨折风险.
科学领域:
- 环境健康 环境健康
- 流行病学 流行病学
- 骨的健康 骨的健康
背景情况:
- 细颗粒物 (PM2.5) 和其成分对骨强度的影响尚不清楚.
- 流行病学研究对于阐明环境健康风险至关重要.
研究的目的:
- 调查个人和联合暴露在PM2.5及其组分与骨强度之间的关联.
- 确定最显著影响骨健康的特定PM2.5成分.
主要方法:
- 利用来自中国多民族队列的65,906名个人 (30-79岁) 的数据.
- 使用卫星遥感和化学物质运输模型估计的PM2.5和成分度.
- 通过骨定量超声指数 (QUI) 评估骨强度,并采用了逻辑回归和加权量子和法.
主要成果:
- 增加对PM2.5,黑碳,,酸盐,有机物和土壤颗粒的暴露与骨强度 (QUI) 有负相关性.
- 在男性,65岁以上的个人,吸烟者和长期饮酒者中,这种关联更强烈.
- 酸盐与骨强度有着特别强烈的负面关联.
结论:
- 长期暴露于PM2.5及其成分可能会降低骨强度,可能增加骨质疏松症和骨折风险.
- 酸盐似乎是导致骨健康下降的关键成分.
- 研究结果强调需要空气质量干预措施来保护骨健康.
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