在小鼠中,S100A9对于肺炎球菌性肺炎的生存是不可或缺的
Lena Ostermann1, Benjamin Seeliger2,3, Sascha David4
1Division of Experimental Pneumology, Hannover Medical School, Hannover, Germany.
PLoS pathogens
|July 19, 2023
概括
S100A9蛋白对于控制肺部细菌感染,特别是肺炎球菌性肺炎至关重要. 它的缺乏导致的增加,细菌的生长和生存率的降低,突出其在免疫防御中的作用.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 肺部病理学 肺部病理学
背景情况:
- 已知S100A8/A9蛋白的免疫调节作用,但其在Streptococcus pneumoniae (S. pneumoniae) 肺炎中的特定功能尚不清楚.
- 细菌性肺炎的诊断可能具有挑战性,需要生物标志物来区分病毒原因.
研究的目的:
- 调查S100A9在对抗S. pneumoniae.宿主防御中的作用.
- 评估S100A9作为细菌性肺炎的潜在生物标志物.
主要方法:
- 从肺炎患者的支气管洗液 (BAL) 中分析S100A9水平.
- 对受到S. pneumoniae.挑战的S100A9淘汰赛 (KO) 小鼠的表型分析.
- 在小鼠模型中评估肺损伤,细菌负载和生存率.
- 用修饰的S100A8/A9蛋白进行化学鼠标研究和治疗干预.
主要成果:
- 细菌性肺炎患者的S100A9水平升高,与前素和SOFA评分相关.
- 在S100A9 KO小鼠中,肺增加,细菌清除受损,存活率降低.
- 中性粒细胞弹性酶介导的集合素降解 (SP-A,SP-D) 导致S100A9 KO小鼠的生存率降低.
- 用稳定S100A8/A9蛋白治疗改善了S. pneumoniae感染的S100A9 KO小鼠的治疗结果.
结论:
- S100A9在肺部的抗菌免疫力中起着至关重要的作用,这对于肺炎球菌性肺炎的生存至关重要.
- S100A9是区分细菌和病毒性肺炎的潜在生物标志物.
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