身体活动,久坐不动行为和胰腺炎风险:孟德尔随机化研究
Ruiqi Ling1, Juan Liang2, Shaojian Mo1
1General Surgery Department, Shanxi Bethune Hospital/General Surgery Department, Third Hospital of Shanxi Medical University, Taiyuan, China.
PloS one
|July 19, 2023
概括
减少休时间的屏幕时间 (LST) 可以预防急性胰腺炎 (AP). 这项研究使用了门德尔的随机化来调查身体活动,久坐行为和胰腺炎之间的因果关系,没有发现与慢性胰腺炎 (CP) 的关联.
科学领域:
- 遗传学 是一个遗传学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 观察性研究表明,身体活动可以预防急性胰腺炎 (AP).
- 然而,身体活动,久坐不动行为和AP/慢性胰腺炎 (CP) 之间的因果关系尚未得到充分证实.
- 门德尔随机化 (MR) 可以通过利用遗传变异来解决这些不确定性.
研究的目的:
- 研究身体活动 (PA) 和久坐行为 (SB) 与急性胰腺炎 (AP) 和慢性胰腺炎 (CP) 之间的因果关系.
- 使用门德尔随机化 (MR) 来评估这些关联,模拟使用遗传数据的随机对照试验.
主要方法:
- 采用孟德尔式随机化 (MR),使用来自英国生物库 (PA,SB) 和FinnGen (AP,CP) 的遗传数据.
- 评估了三个身体活动模式 (MVPA,AccAve,Acc425) 和三个久坐行为模式 (LST,久坐通勤,工作时久坐行为).
- 使用逆方差加权 (IVW),加权中位数和MR-Egger方法,以及包括科克兰Q测试,MR-Egger拦截和MR-PRESSO在内的灵敏度分析.
主要成果:
- 在休屏幕时间 (LST) 和急性胰腺炎 (AP) 风险增加之间确定了显著的因果关系 (OR=1.38,95% CI=1.16-1.64,p=0.0002).
- 身体活动或其他久坐行为与急性或慢性胰腺炎之间没有发现显著的因果关系.
- 敏感性分析证实了研究结果的可靠性,表明没有显著的类或异质性.
结论:
- 减少休时间的屏幕时间 (LST) 是预防急性胰腺炎 (AP) 的潜在策略.
- 这一发现表明AP的可修改风险因素,可能降低相关的健康负担.
- 在这项MR研究中,没有确定身体活动或其他久坐行为与胰腺炎的因果关系.
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