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TOX2与TET2协调,以积极调节人类CAR T细胞中的中央记忆分化

Sierra M Collins1, Katherine A Alexander1, Stefan Lundh2

  • 1Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Science advances
|July 19, 2023
PubMed
概括

减少TET2基因可以促进中央记忆T细胞 (TCM),这对CAR T细胞治疗至关重要. 失去TET2会增加TOX2的表达,增强TCM的分化,并可能提高癌症治疗的疗效.

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