相关实验视频
Updated: Jul 23, 2025

A Murine Model of Group B Streptococcus Vaginal Colonization
Published on: November 16, 2016
婴儿B组链球菌疫苗的孕产妇疫苗的潜力
Shabir A Madhi1, Annaliesa S Anderson1, Judith Absalon1
1From the South African Medical Research Council Vaccines and Infectious Diseases Analytics Research Unit (S.A.M., R. Strehlau, A.I., G.K., S.J., L.J.), the Department of Paediatrics and Child Health, Faculty of Health Sciences, Rahima Moosa Mother and Child Hospital (R. Strehlau), and Wits RHI, Faculty of Health Sciences, University of the Witwatersrand (L.F.), Johannesburg, the Division of Neonatal Medicine, School of Child and Adolescent Health, Faculty of Health Sciences, University of Cape Town, and Mowbray Maternity Hospital, Cape Town (A.M.N.), the Clinical Neonatology Unit, Prince Mshiyeni Memorial Hospital (N.N.), and the Department of Medical Microbiology, National Health Laboratory Services, Prince Mshiyeni Memorial Hospital and College of Health Sciences, University of KwaZulu-Natal (Y.R.), Durban, the University of Pretoria and the Tshwane Academic Division, National Health Laboratory Services, Pretoria (M.S.), and the Family Center for Research with Ubuntu, Department of Paediatrics and Child Health, Stellenbosch University, Stellenbosch (S.L.B.) - all in South Africa; and Vaccine Research and Development, Pfizer, Pearl River, NY (A.S.A., J.A., D.R., R. Simon, B.J., R.N., S.M., Z.J., D.P., N.C.S.M., E.G., J.L.P., D.A.S., W.C.G., K.U.J.).
一种新的孕产妇疫苗,GBS6,在预防婴儿的侵袭性B型 estreptococcal 疾病方面表现有前途. 疫苗在母亲中引起保护性抗囊多糖体IgG抗体,这些抗体被转移到新生儿身上,降低了疾病风险.
科学领域:
- 产科和妇科 产科和妇科
- 儿科 儿科 儿科
- 免疫学 免疫学 免疫学
背景情况:
- 自然史研究将新生儿的抗囊多糖体 (CPS) IgG与B型 estreptococcal (GBS) 疾病风险降低联系起来.
- 一种六价的CPS交叉反应物质197糖联疫苗 (GBS6) 正在开发中,作为一种孕产妇疫苗.
研究的目的:
- 评估GBS6在孕妇中的安全性和免疫性.
- 在婴儿中分析母体转移的抗CPS抗体.
- 在新生儿中定义针对侵入性GBS疾病的保护性抗体值.
主要方法:
- 在孕妇中进行GBS6的第二阶段,安慰剂对照试验.
- 在婴儿中,并行血清流行病学研究将抗CPSIgG与降低GBS疾病风险相关联.
- 对安全性,免疫性和母婴抗体转移的评估.
主要成果:
- 自然获得的抗CPSIgG度与婴儿GBS疾病风险降低相关.
- 确定了假定保护性IgG值 (0.1840.827μg/mL,可降低7595%的风险).
- GBS6是安全的;在母亲或婴儿中没有观察到显著的安全信号. GBS6诱导了母亲的反应,并将抗体转移到婴儿身上 (比率为0.41.3).
结论:
- 孕妇接种GBS6疫苗会产生抗GBS抗体.
- 这些抗体转移到婴儿身上,达到与减少侵入性GBS疾病风险相关的水平.
- 这项研究支持GBS6作为一种潜在的孕产妇疫苗,用于预防婴儿GBS疾病.
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