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瘦素缺乏会损害小鼠中细胞原始体的脂肪生成和色反应

Ksenija Velickovic¹, Hilda Anaid Lugo Leija², Bojana Kosic³

¹School of Medicine, The University of Nottingham, UK; Faculty of Biology, The University of Belgrade, Serbia.

European journal of cell biology

|July 19, 2023

概括

莱普支持脂肪细胞的色,增强其产生热量的能力. 瘦素缺乏会损害这一过程,这表明瘦素在热生成和脂肪生成中起着关键作用.

科学领域:

代谢过程中的代谢.
细胞生物学细胞生物学
内分泌学在内分泌学.

背景情况:

棕色脂肪组织 (BAT) 和部白色脂肪组织 (iWAT) 通过使用UCP1.1的非热生成产生热量.
布朗宁描述了iWAT中热生活跃的色脂肪细胞的出现.
介酶干细胞 (MSC) 产生棕色和色脂肪细胞,棕色通过低温在培养中可诱导.

研究的目的:

为了研究素在脂肪细胞的细胞色反应中的作用.
为了确定瘦素信号是否影响棕色和色脂肪细胞标记物的表达.
阐明丁在脂肪生成和棕色化中的潜在参与.

主要方法:

对MSC衍生的脂肪细胞进行免疫细胞化学分析,以检测核瘦素和瘦素受体.
从缺乏叶黄素 (ob/ob) 的小鼠和野生类型的对照中分析了BAT和iWAT.
在不同温度下,在培养中将MSC分化为脂肪细胞,含有和没有勒.

主要成果:

在MSC衍生的脂肪细胞中,丁及其受体的核定位表明丁途径参与色.
瘦素缺乏的小鼠在BAT和iWAT中表现出棕色/色脂肪细胞标记物的减少表达.
在培养的MSC中,素缺乏诱导了白色脂肪细胞表型,特别是在32°C时,具有受损的脂肪基差异化.

结论:

莱普在脂肪细胞色过程中起到支持作用.
莱普信号传递对于热能活跃的色脂肪细胞的发展至关重要.
丁可能是脂肪生成和色过程的重要调节者.

关键词:

增脂生殖是一种增脂的过程.布朗宁是什么意思布朗宁是什么意思勒普丁是一种激素.勒普丁受体的受体是什么?原始人的祖先解蛋白1 (UCP1) 是一种解蛋白.

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