天然和半合成碳醇类化合物的抗菌活性
Yan-Yan Ding1, Han Zhou2, Peng-Deng2
1School of Pharmacy, Lanzhou University, Lanzhou, 730000, China; Key Laboratory of Vector Biology and Pathogen Control of Zhejiang Province, College of Life Science, Huzhou University, Huzhou, 313000, China.
European journal of medicinal chemistry
|July 19, 2023
概括
本综述详细介绍了2012年至2022年间发现的碳醇类化合物的抗真菌和抗菌活性. 它总结了关于天然和合成衍生物的发现,强调了它们在医学中的潜力.
科学领域:
- 药用化学 医学化学
- 自然产品 化学 化学
- 药理学 药理学是指药理学的学科.
背景情况:
- 从Mwraya Spreng中首次分离出来的碳素类化合物,表现出多种生物活性,包括抗瘤,抗病毒和抗菌性质.
- 最近的研究表明,与碳醇类及其衍生物相关的生物活动范围广泛.
- 关于这些化合物的全面抗真菌和抗菌潜力,存在重大知识差距.
研究的目的:
- 提供在过去十年 (2012-2022) 报告的碳醇类化合物的抗真菌和抗菌活性的首次全面审查.
- 为了整合有关自然存在和部分合成的碳醇类衍生物的信息.
- 确定当前的挑战和未来的方向,在这个领域的研究.
主要方法:
- 2012年至2022年科学出版物的系统文献综述.
- 包括报告自然和合成碳醇类化合物的抗真菌和抗菌功效的研究.
- 对化合物结构,活动和作用机制的数据的分析和合成.
主要成果:
- 许多碳醇类衍生物已经显示出对一系列病原体具有显著的抗真菌和抗菌活性.
- 无论是天然产品还是半合成改造,都显示出有前途的效果,具有不同程度的效力和活性范围.
- 在几个化合物类中,已经确定了有助于抗微生物疗效的特定结构特征.
结论:
- 碳醇类化合物是开发新型抗真菌和抗菌剂的有希望的化合物类别.
- 需要进一步的研究来克服与合成,生物可用性和耐药性相关的挑战.
- 本综述是未来对碳醇类化合物的探索和治疗应用的宝贵资源.
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