通过重建瘤微环境,Crocus sativus花多糖的抗瘤作用
Jue Tu1, Yanfei He2, Huifang Zhang3
1College of Animal Sciences, Zhejiang University, Hangzhou 310058, China; Laboratory Animal Research Center, Academy of Chinese Medical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China.
International journal of biological macromolecules
|July 19, 2023
概括
克罗库斯的花多糖PCSPB通过抑制小鼠的肉瘤生长表现出显著的抗瘤作用. 它有效调节瘤微环境,增强免疫细胞活性并减少免疫抑制因素.
科学领域:
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
- 生物化学 生化学
背景情况:
- 来自Crocus sativus花 (PCSPs) 的多糖体表现出免疫潜能.
- PCSPB已经显示出提高小鼠先天免疫力的潜力.
研究的目的:
- 为了评估PCSPB的抗瘤活性.
- 研究瘤微环境 (TME) 中PCSPB的免疫机制.
主要方法:
- 带有肉瘤的S180小鼠模型.
- 组织学分析 (HE染色,免疫组织化学,TUNEL测定).
- 细胞因子水平的分析 (TGF-β,IFN-γ,IL-10,TNF-α).
- 免疫细胞群 (CD8+ T细胞,NK细胞,Tregs,MDSCs,TAMs) 的流细胞计.
- 对TAM极化进行免疫光试验.
主要成果:
- 根据剂量,PCSPB显著抑制了S180肉瘤的生长.
- 诱导瘤细胞死亡,细胞亡和血管干扰.
- 降低免疫抑制性细胞因子 (TGF-β,IL-10) 和炎症因子 (IFN-γ,TNF-α) 的水平.
- 增加了CD8+ T细胞和NK细胞,同时减少了Tregs,MDSCs和TAMs.
- 在TME中重新编程M2 TAM到M1表型.
结论:
- PCSPB具有强大的抗瘤活性,具有低毒性.
- PCSPB重建瘤微环境以发挥其抗瘤作用.
- PCSPB是抗癌疗法的有希望的候选者.
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