基于机器学习的疾病预防的个人健康疾病阶段图
Kazuki Nakamura1, Eiichiro Uchino2, Noriaki Sato2
1Department of Biomedical Data Intelligence, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan; Research and Business Development Department, Kyowa Hakko Bio Co., Ltd., Tokyo 100-0004, Japan.
一个新的健康疾病阶段图 (HDPD) 可视化了个人的健康状况,并预测了疾病的发病. 在HDPD中调整生物标志物成功地预防了11种疾病中的7种疾病的未来疾病,有助于早期预防疾病.
科学领域:
- 生物医学信息学 生物医学信息学
- 计算生物学 计算生物学
- 预防医学 预防医学
背景情况:
- 精准医学突出了个体健康数据的异质性和复杂的慢性疾病因素.
- 机器学习能够使用多变量数据进行个性化疾病预测.
- 鉴定疾病预防的具体干预目标仍然具有挑战性,因为复杂的生物标志物相互依赖.
研究的目的:
- 引入健康-疾病阶段图 (HDPD) 以可视化个人健康状况和预测未来疾病发病.
- 为了证明HDPD在指导疾病预防干预措施中的实用性.
主要方法:
- 开发了HDPD来表示个体健康状况,通过可视化早期波动生物标志物的未来开始边界值.
- 通过扰乱多个生物标志物值,考虑可变依赖性来建模未来开始的预测.
- 用3,238个人的纵向数据构建了11种疾病的HDPD,包括3,215个测量项目和遗传数据.
主要成果:
- HDPD有效地代表疾病发作期间的个体生理状态.
- 在HDPD框架内改善非发病区域的生物标志物值,在研究的11种疾病中的7种疾病中预防了未来的疾病发病.
- 显示了HDPD指导干预措施对疾病预防的重大影响.
结论:
- HDPDs提供了一种新的方法来可视化和理解个体疾病的进展.
- HDPD可以作为积极预防疾病战略的有效干预目标.
- 这种方法对推进个性化和预防性医疗保健充满希望.
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