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通过内源性神经生长因子含有生物活性纤维膜的内源性神经生长因子实现受伤的洞穴神经的功能恢复

Marta R Casanova¹, Paulo Mota², Helena Vala³

¹3B's Research Group; I3Bs - Research Institute on Biomaterials, Biodegradable and Biomimetics - University of Minho, European Institute of Excellence in Tissue Engineering and Regenerative Medicine Headquarters, Parque de Ciência e Tecnologia, Zona Industrial da Gandra - Avepark, Barco, Guimarães 4805-017, Portugal; ICVS/3B's - PT Government Associate Laboratory, Guimarães/Braga, Portugal.

Acta biomaterialia

|July 19, 2023

概括

一种新的生物活性纤维膜,使用尿液中的神经生长因子 (NGF) 来个性化,有效地再生洞穴神经 (CN),并在受伤后恢复勃起功能. 这种方法为前列腺切除术后勃起功能障碍 (ED) 提供了有前途的治疗方法.

科学领域:

再生医学是一种再生医学.
生物材料科学生物材料科学
泌尿器科泌尿器科泌尿器科泌尿器科

背景情况:

根性前列腺切除术是前列腺癌的常见治疗方法,由于洞穴神经 (CN) 损伤,往往导致勃起功能障碍 (ED).
目前治疗术后勃起障碍的方法存在局限性,这凸显出需要创新的再生策略.

研究的目的:

调查个性化的生物活性纤维膜在再生受伤的洞穴神经 (CN) 中的有效性.
评估这种膜在进行激进前列腺切除术后恢复勃起功能的潜力.

主要方法:

开发一种生物活性纤维膜,其功能是从老鼠尿中选择性地结合神经生长因子 (NGF).
在双边CN压伤的老鼠模型中植入膜.
评估神经再生,阴茎结构和勃起功能恢复.

主要成果:

生物活性纤维膜显著促进了CN再生,由肌化轴突和神经元氧化合成酶 (nNOS) 阳性细胞的增加证明.
观察到勃起功能恢复,光滑肌肉细胞和氧化合成酶 (eNOS,nNOS) 含量增加.
与未经处理或裸膜对照组相比,膜逆转了CN纤维化.

结论:

一种个性化,生物活性,无细胞的纤维植入物显示出治疗神经元损伤和恢复勃起功能的巨大潜力.
这种再生策略可以克服目前在前列腺切除术后治疗ED方面的局限性,为患者提供量身定制的解决方案.

关键词:

生物活性的纤维膜膜.勃起功能障碍是因为勃起功能障碍.个性化治疗是个性化的治疗.前列腺癌是什么意思前列腺癌是什么意思进行前列腺切除术.

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