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A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice
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支气管镜检查耐火/无法解释的含有粘液的咳.

James Wingfield Digby1, Jenny King1, Bashar Al-Sheklly2

  • 1School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom; NIHR Manchester Biomedical Research Centre, Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom.

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此摘要是机器生成的。

支气管镜检查对于诊断具有粘液产生的耐火/不明原因咳 (RUCC) 有价值. 它确定了可治疗的疾病,如中性友气道炎症和过度动态气道崩 (EDAC),指导这些患者的管理.

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科学领域:

  • 肺部病理学 肺部病理学
  • 呼吸系统医学 呼吸系统医学
  • 诊断程序 诊断程序 诊断程序

背景情况:

  • 耐火性/不明原因咳 (RUCC) 通常伴有喉症状和干燥咳.
  • 一部分患有RUCC的患者报告了显著的唾液产生和胸部感觉,支气管镜检查数据有限.
  • 在RUCC与粘液中的支气管镜检测结果的特征对于理解潜在的病理学至关重要.

研究的目的:

  • 为了评估支气管镜检查,支气管支气管洗 (BAL) 细胞差异和RUCC患者的微生物学发现.
  • 为了确定该患者队列中的特定可治疗的特征.
  • 评估支气管镜对治疗策略的影响.

主要方法:

  • 病例笔记和手术结果的回顾性回顾,对接受RUCC支气管镜检查的患者,每天吐>1大匙.
  • 纳入标准:RUCC,正常/微不足道的CT发现,对指导方针治疗没有反应.
  • 分析BAL细胞差异和识别气道崩在支气管镜检查期间.

主要成果:

  • 包括54名RUCC和粘液产生患者.
  • 84%的患者表现出BAL中性友好症,表明呼吸道炎症.
  • 在31%的患者中观察到过度动态气道崩 (EDAC).
  • 支气管镜检查结果影响或改变了89%的患者的治疗方法.

结论:

  • 支气管镜在RUCC中具有很高的诊断价值,具有显著的粘液产量.
  • 识别特定可治疗的特征,如中性友气道炎症和EDAC.
  • 支气管镜检查结果对这一患者群体的治疗策略产生重大影响和指导.