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适度CKD成年人的肠道微生物群和尿液保留溶液:为期6天的受控养研究
Gretchen N Wiese1, Annabel Biruete2, Elizabeth R Stremke3
1Department of Nutrition Science, Purdue University, West Lafayette, Indiana; US Renal Care, Lone Tree, Colorado.
概括
与对照人群相比,慢性脏病 (CKD) 患者的印氧硫酸盐,p-cresol硫酸盐和三甲基胺N-氧化物的血清度显著更高. 控制饮食后,肠道微生物群的组成在各组之间没有差异.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 胃肠病学 胃肠病学
- 代谢学 代谢学 代谢学
背景情况:
- 尿液保留溶液 (URS) 如硫酸 (IS),硫酸 (PCS) 和三甲基胺N氧化物 (TMAO) 与慢性病 (CKD) 的进展有关.
- 肠道微生物群在URS产生中的作用及其在CKD中的改变尚未完全理解.
- 控制养研究提供了一种方法来分离饮食对URS和微生物群的影响.
研究的目的:
- 为了比较IS,PCS和TMAO的血清和尿液度.
- 分析中度慢性脏病患者的肠道微生物群组成,与匹配的对照组相比.
- 在为期6天的受控养研究中调查这些因素.
主要方法:
- 一项为期6天的受控养研究的二次分析,涉及8名中度CKD的成年人和8名匹配的对照.
- 在血清,尿液和便样本中量化IS,PCS和TMAO,使用液态染色体质谱法.
- 通过多样性和种群丰度分析评估肠道微生物群组成.
主要成果:
- 与对照组相比,CKD患者的IS,PCS和TMAO血清度显著升高 (2.8至4.9倍).
- 在CKD和对照组之间没有观察到肠道微生物群组成 (α-多样性,β-多样性) 的显著差异.
- 估计的淋巴细胞过率 (eGFR) 显示,在CKD患者中与血清URS,特别是IS和TMAO的反向关系.
结论:
- 患有CKD的成年人与匹配的非CKD成年人相比,呈现出较高的血清URS水平,无论控制饮食后肠道微生物群的组成如何.
- 这项研究强调了在CKD中血清URS显著增加.
- 需要进一步的研究来探索特定的饮食成分如何影响CKD中的微生物群和URS生产.
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