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电子烟电子液体和设备功率对血管功能的影响

Amber Mills¹, James Frazier², Rachel Plants²

¹Department of Physiology, Pharmacology and Toxicology, West Virginia University School of Medicine, Morgantown, WV 26506, United States of America; Center for Inhalation Toxicology, West Virginia University School of Medicine, Morgantown, WV 26506, United States of America.

Toxicology and applied pharmacology

|July 19, 2023

概括

电子烟 (e-cig) 气溶来自植物甘油 (VG) 或甘醇 (PG) 损害了血管功能,特别是在像中脑动脉 (MCA) 这样的较小动脉中. 瓦特设置也会影响电子烟的气溶效应.

科学领域:

心血管研究研究心血管研究
毒理学毒理学毒理学
血管生物学血管生物学

背景情况:

电子烟 (e-cigs) 提供可定制的用户体验,包括电子液体成分和瓦量.
由于电子烟的广泛使用,了解电子烟气溶对血管的影响至关重要.

研究的目的:

为了比较导动动脉 (胸前动脉) 和阻力动脉 (中脑动脉,MCA) 在暴露于电子烟气溶后的血管结果.
调查不同电子液体组件 (VG与PG) 和功率设置对血管功能的影响.

主要方法:

小鼠 (C57Bl/6) 被暴露在纯植物甘 (VG) 或纯甘 (PG) 产生的电子烟气溶中.
第一项研究涉及60分钟的曝光,而第二项研究则研究了100分钟的5瓦和30瓦设置.
对胸前大动脉和MCA的内皮依赖扩张 (EDD) 进行了评估.

主要成果:

在研究1中,PG气溶导致大动脉EDD受损. 在VG和PG两组中,MCA EDD受损了50%左右.
在研究2中,大动脉EDD不受瓦功率的影响,但MCAEDD在5瓦 (32%) 和30瓦 (55%) 设置时显著受损.
血管功能障碍在MCA中比在主动脉中更明显,在所有暴露条件下.

结论:

暴露在电子烟气溶中,无论VG/PG成分或功率如何,都会引起血管功能障碍.
阻力动脉,如MCA,似乎对电子烟气溶诱导的血管功能障碍更敏感,而不是像大动脉这样的导动脉.
这些发现表明基于动脉层次的血管损伤的潜在差异机制.

关键词:

大动脉的大动脉.脑子脑子脑子脑子中脑动脉中脑动脉肌肉图谱肌肉图谱是指肌肉图谱,是指肌肉图谱.电子烟 Vaping 是一种电子烟.

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