代谢功能障碍:与脂肪肝疾病的沉默联系
Mariana M Ramírez-Mejía1, Xingshun Qi2, Ludovico Abenavoli3
1Plan of Combined Studies in Medicine (PECEM-MD/PhD), Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico; Liver Research Unit, Medica Sur Clinic & Foundation, Mexico City, Mexico.
Annals of hepatology
|July 19, 2023
概括
建议将代谢功能障碍相关的脂肪肝疾病 (MAFLD) 取代非酒精性脂肪肝疾病 (NAFLD),以更好地反映代谢风险因素. 本综述探讨了对MAFLD的转变,以全面了解脂肪肝疾病.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 代谢疾病 代谢疾病
- 公共卫生 公共卫生
背景情况:
- 非酒精性脂肪肝 (NAFLD) 是一个日益严重的全球健康问题,经常被糖尿病和肥胖等相关疾病所掩盖.
- 尽管NAFLD的流行率很高,但从历史上看,它缺乏足够的研究重点和明确的诊断标准.
- 脂肪肝疾病的代谢基础越来越被认为是其病理生理学的核心.
研究的目的:
- 审查将NAFLD重新命名为与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 的历史背景和科学理由.
- 检查将代谢功能障碍与脂肪肝疾病联系在一起的病理生理机制.
- 讨论采用MAFLD分类和诊断标准的临床影响和益处.
主要方法:
- 关于脂肪肝疾病的历史,病理生理和临床研究的文献综述.
- 对MAFLD提出的诊断标准的分析.
- 对NAFLD与MAFLD的比较评估. 名称和临床范围.
主要成果:
- 拟议的MAFLD标准旨在涵盖由代谢功能障碍驱动的脂肪肝疾病的全谱.
- 换名承认代谢因素的首要作用,无论BMI或同时存在的肝脏疾病.
- MAFLD的方法有助于更准确的诊断和有针对性的管理策略.
结论:
- 从NAFLD过渡到MAFLD代表了理解和管理脂肪肝疾病的关键范式转变.
- MAFLD提供了一个更精确,更具包容性的框架,强调肝病中的代谢健康.
- 采用MAFLD对于推进代谢相关脂肪肝疾病的研究,诊断和治疗至关重要.
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