高风险软组织肉瘤治疗中的高热量:系统性审查
Paraskevi Danai Veltsista1, Eva Oberacker1, Adela Ademaj2,3
1Department of Radiation Oncology, Charité Universitätsmedizin Berlin, Berlin, Germany.
概括
区域性高温症 (RHT) 在与化疗或放射治疗相结合时,有望改善软组织肉瘤 (STS) 的存活率. 需要进一步的研究,以优化其融入多式联络治疗策略.
科学领域:
- 在瘤学瘤学.
- 医学物理 医学物理
背景情况:
- 高危软组织肉瘤 (STS) 存在复杂的治疗挑战.
- 区域性高温症 (RHT) 正在作为一种辅助疗法进行研究,以改善结果.
- 为了将RHT最好地整合到多式联运STS治疗中,需要进一步澄清.
研究的目的:
- 系统地审查有关将区域性高温症 (RHT) 纳入软组织肉瘤 (STS) 多模式治疗的文献.
- 评估RHT在STS治疗中与化疗 (CTX) 和/或放射治疗 (RT) 结合时的有效性和可行性.
主要方法:
- 按照PRISMA指南进行了一次系统的文献审查.
- 包括专注于放射性RHT和表面高温的研究.
- 被排除的研究涉及儿科患者,转移性疾病或是评论文章.
主要成果:
- 分析了从1990年到2022年的15份临床报告.
- 评估了与化疗 (CTX) 或放射治疗 (RT) /化疗放射治疗 (CRT) 结合的RHT.
- RHT显示RT的有效性增加,特别是在每周两次治疗时,三种模式的新辅助RHT和CRT是可行的,没有显著的毒性.
结论:
- 审查的数据支持RHT在多模式STS治疗中的有益作用.
- 需要进一步的专家共识和临床试验,以建立最佳的RHT整合协议用于STS治疗.
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