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Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

154
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
154
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
356
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

296
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
296
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

220
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
220
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF01:24

Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF

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Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
174
Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

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Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
171

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Chronic Salmonella Infection Induced Intestinal Fibrosis
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炎症性肠病:最近的发展

James John Ashton1,2, R Mark Beattie3

  • 1Department of Paediatric Gastroenterology, Southampton Children's Hospital, Southampton, UK.

Archives of disease in childhood
|July 19, 2023
PubMed
概括
此摘要是机器生成的。

儿童炎症性肠病 (IBD) 在儿童中正在上升,有新的诊断工具和先进的治疗方法,如生物药物. 个性化治疗策略是管理年轻患者这种复杂疾病的关键.

关键词:
胃肠病学 胃肠病学儿科 儿科 儿科

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科学领域:

  • 儿科胃肠病学 儿科胃肠病学
  • 免疫学 免疫学 免疫学
  • 内部医学 内部医学

背景情况:

  • 儿科发病的炎症性肠病 (IBD) 发病率在25年内翻了一番,患病率和严重程度不断增加.
  • 儿童IBD的诊断工具已经进步,包括便calprotectin,小肠成像和囊内镜.
  • 管理选择已经扩大,包括新的向疗法和改进的药物监测.

研究的目的:

  • 总结了儿科IBD的诊断,调查和管理方面的最新进展.
  • 突出IBD护理对儿童和年轻人的不断变化的景观.
  • 讨论个性化和分层治疗方法的未来.

主要方法:

  • 关于儿科IBD诊断和管理的最新文献的综述.
  • 分析诊断技术的进步.
  • 评估新兴的治疗策略和监测技术.

主要成果:

  • 通过便calprotectin和高级成像等工具提高了诊断准确度.
  • 引入向疗法 (例如,抗IL-12/23,JAK-STAT抑制剂) 和精细监测已建立的治疗方法.
  • 承认IBD是一种具有多样化表型的疾病连续体.

结论:

  • 最近的发展为儿科IBD提供了改进的诊断和管理选择.
  • 使用生物标志物的个性化和分层治疗策略对于未来的护理至关重要.
  • 临床网络内的多学科合作对于儿科IBD的最佳结果至关重要.