欧米茄-3脂肪酸生物标志物和发生心房的事件
Frank Qian1, Nathan Tintle2, Paul N Jensen3
1Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Journal of the American College of Cardiology
|July 19, 2023
概括
包括EPA,DPA和DHA在内的欧米茄-3脂肪酸与心房动 (AF) 的风险增加无关. 这些发现支持目前关于鱼类和omega-3摄入量的饮食建议的安全性.
科学领域:
- 心血管研究研究心血管研究
- 营养科学 营养科学
- 流行病学 流行病学
背景情况:
- 欧米茄-3脂肪酸和心房动 (AF) 之间的关联是有争议的.
- 之前的研究已经产生了关于omega-3s对AF风险的影响的相互矛盾的结果.
研究的目的:
- 调查血液或脂肪组织中特定omega-3脂肪酸水平与AF发病率之间的潜在关系.
- 为了澄清埃可萨氨酸 (EPA),多可萨氨酸 (DPA) 和多可萨赫萨氨酸 (DHA) 在AF发展中的作用.
主要方法:
- 利用了来自17项国际前性队列研究的综合数据.
- 在各个研究中应用了对暴露,结果和共变量的协调定义.
- 采用反变量加权的元分析,结合了新作分析的结果.
主要成果:
- 对54,799名参与者的分析显示,在13.3年的中位数随访期间,发生了7,720起发生的AF病例.
- 在EPA水平和事件AF之间没有发现显著的关联 (HR1.00;95%CI:0.95-1.05).
- 较高的DPA,DHA和EPA+DHA水平显示出发生AF的风险降低 (HRs从0.89到0.93).
结论:
- 在体内Omega-3脂肪酸水平 (EPA,DPA,DHA) 与发展AF的更高风险无关.
- 习惯性通过饮食摄入omega-3脂肪酸似乎是安全的关于AF风险.
- 考虑到它们对心血管的益处,可以保持目前对鱼类和omega-3消费的饮食指南.
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