腹腔透析患者的脆弱性临床影响 - 一项前性观察性研究
Yi-Ting Chen1, Tai-Shuan Lai2, Hsiao-Mei Tsao2
1Division of Nephrology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan; Division of Blood Purification, Department of Integrated Diagnostics & Therapeutics, National Taiwan University Hospital, Taipei, Taiwan.
概括
在腹膜透析患者中,虚弱是常见的. 年轻的新发病患者在六个月内表现出改善的脆弱性,但糖尿病和痛风等并发症比脆弱性本身更好地预测不良结果.
科学领域:
- 老年病学和科.
- 临床流行病学临床流行病学
背景情况:
- 虚弱是一种与年龄相关的严重疾病,与不良健康结果有关.
- 它的临床影响和周周透析 (PD) 患者的演变需要彻底调查.
研究的目的:
- 调查在接受腹腔透析 (PD) 的患者中虚弱演变的临床影响.
- 评估新发病和流行PD患者的脆弱状态及其在六个月内的变化.
主要方法:
- 一项涉及337名PD患者 (新发病和流行) 的前性研究.
- 使用80个风险因素 (FI80) 的半自动脆弱指数和基线和6个月的Fried脆弱表型进行脆弱性评估.
- 脆弱性定义为FI80分数≥13/80或Fried表型分数≥3/5.5的脆弱性.
主要成果:
- 在59.3% (FI80) 和48.4% (表型) 的PD患者中,脆弱性很普遍.
- 较年轻的新发病的PD患者 (<55岁) 显示出最好的脆弱性演变 (61.7%稳定或改善).
- 虽然虚弱预测了医疗保健服务利用率的增加,但糖尿病,痛风和低BMI是整体死亡和住院治疗的更强有力的预测因素.
结论:
- 在PD患者中,虚弱是常见的,在年轻,新发病的个体中,可能会出现短期改善.
- 在这个人群中,并发病 (糖尿病,痛风) 和营养不良是不利结果的更强有力的预测因素,而不是脆弱.
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