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在COPD患者中对百日咳疫苗的免疫反应
E Feredj1,2, A Wiedemann3,4, C Krief3,4
1Infectious Disease Department, AP-HP (Assistance Publique-Hôpitaux de Paris), Groupe Hospitalier Henri-Mondor/Albert Chenevier, 94010, Créteil, France. elsa.feredj@gmail.com.
Scientific reports
|July 19, 2023
概括
慢性阻塞性肺病 (COPD) 患者对百日咳疫苗接种表现出有效的免疫反应,类似于健康个体. 这一发现支持了Tdap增强疫苗对这一弱势群体的重要性.
科学领域:
- 免疫学 免疫学 免疫学
- 肺部病理学 肺部病理学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 呼吸道感染显著增加了COPD患者的发病率和死亡率.
- 以前的研究表明,COPD患者对流感疫苗的免疫反应降低,这引发了对该群体疫苗有效性的担忧.
研究的目的:
- 为了评估稳定的COPD患者对百日咳疫苗接种的幽默和细胞免疫反应.
- 为了比较COPD患者和健康志愿者之间接种百日咳疫苗的免疫反应.
主要方法:
- 前性,单中心,纵向研究设计.
- 包括13名稳定的COPD患者和8名健康志愿者.
- 疫苗接种后循环B和T细胞子集,TFH细胞,等离子体,百日咳特异性抗体和ex-vivo CD4+ T细胞反应的评估.
主要成果:
- 在COPD患者和健康志愿者之间,基线B和T细胞子集没有显著差异.
- 在接种疫苗后的两组中,类似地诱导了TFH细胞,血芽细胞和百日咳特异性抗体.
- 在COPD患者和健康对照群中,在活体刺激后,对功能性和特定的CD4+T细胞 (IFNγ,TNFα,IL-2) 的等效诱导.
结论:
- 在COPD患者中,百日咳疫苗接种在免疫学上是有效的,这挑战了一般性疫苗不反应的概念.
- 医疗保健提供者应该强调每十年一次的Tdap增强疫苗对COPD患者的重要性.
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