有证据表明,大量的跨状交替电流刺激直接进入大脑深层区域
Yongzhi Shan1,2,3, Hongxing Wang4,5, Yanfeng Yang1,2,3
1Department of Neurosurgery, Xuanwu Hospital, National Center for Neurological Disorders, National Clinical Research Center for Geriatric Diseases, Capital Medical University, Beijing, 100053, China.
Molecular psychiatry
|July 19, 2023
概括
跨交替电流刺激 (tACS) 有效地将电流传递到像海马体,胰岛和杏仁体这样的大脑深处的区域. 这一发现支持tACS作为神经精神疾病的潜在治疗方法.
科学领域:
- 神经科学是一个神经科学.
- 神经调节是一种神经调节.
- 医疗工程 医疗工程
背景情况:
- 包括海马体,胰岛体和杏仁体在内的深层大脑结构与慢性失眠和抑郁症等神经精神疾病有关.
- 以前的研究表明,在8周内,15mA和77.5Hz的跨交替电流刺激 (tACS) 对这些疾病是安全有效的.
- 有关tACS电流向清醒人类深层脑组织传递的物理证据存在关键的知识差距.
研究的目的:
- 在清醒的人类中使用tACS提供直接的物理证据,证明电流向大脑深部区域 (海马体,胰岛,杏仁体) 传递.
- 在这些深层大脑结构中研究tACS电流强度和局部场潜在 (LFPs) 之间的关系.
- 通过tACS.确定通过tACS.显著调节深层大脑活动的最小有效电流强度.
主要方法:
- 在11名患者中,用立体电脑电图 (SEEG) 电极直接记录了海马,胰岛和杏仁体的局部场势 (LFP).
- 患者接受77.5赫兹的tACS,电流强度从1mA到15mA,每个电流水平的具体持续时间.
- 使用线性回归分析将记录的LFP与应用的tACS电流强度相关联,并对多次比较进行调整.
主要成果:
- 在海马体,胰岛体和杏仁体中应用的tACS电流和平均LFP之间发现了统计学上显著的关联 (p < 0.050.01).
- 与基线 (0 mA) 相比,在交替电流超过7 mA (p < 0.05) 时,观察到LFPs的显著差异.
- 即使经过多次比较的调整,这些显著差异仍然存在,这证实了研究结果的稳定性.
结论:
- 这项研究提供了第一个直接证据,即特定的tACS协议可以有效地将电流传递给人类深层脑组织.
- 这些发现证实了tACS用于调节海马,胰岛和杏仁体的神经活动的使用.
- tACS为未来治疗与这些关键大脑区域相关的神经精神疾病提供了一个有希望的,基于证据的途径.
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