推动人类大脑演变的细胞复杂性
Emre Caglayan1,2, Fatma Ayhan1,2, Yuxiang Liu1,2
1Department of Neuroscience, UT Southwestern Medical Center, Dallas, TX, USA.
Nature
|July 19, 2023
概括
人类大脑的进化涉及到独特的基因组变化. 这项研究揭示了人类和灵长类动物之间的细胞类型特定的分子和调节差异,揭示了人类大脑创新的机制.
科学领域:
- 进化生物学
- 神经科学
- 基因组学
背景情况:
- 人类特异性基因组改变是人类独特大脑功能的基础.
- 细胞多样性和复杂的基因调控需要对人类特有的分子特征进行细胞分辨率分析.
研究的目的:
- 在细胞分辨率下描述人类特有的分子和调节特征.
- 确定对人类大脑进化的基因组区域和调节机制.
主要方法:
- 分析单核RNA测序 (snRNA-seq) 和对转化酶可访问的染色体的单核测定与测序 (snATAC-seq) 数据
- 对人类,黑猩猩和 rhesus macaques (后带皮层) 的脑组织进行比较分析.
主要成果:
- 观察到人体特异性转移的寡细胞群 (增加的前代细胞,减少的成熟细胞).
- 鉴定了包括FOXP2上调在内的原细胞和神经元亚型的加速人体特异性调控变化.
- 发现了数百个具有改变色素可访问性的人类加速基因组区域 (HAR),在刺激神经元中为FOS::JUN和FOX动机进行了丰富.
结论:
- 揭示了驱动人类大脑进化的细胞类型特异性的新分子和调节机制.
- 突出了寡细胞发育和特定转录因子在人类神经创新的作用.
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