PFAS暴露对甲状腺激素疾病和胆固醇水平的影响之间的干扰:一个NHANES分析
Liang Zheng1, Zhecun Wang2, Rui Yang3
1Department of Thyroid Surgery, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510080, Guangdong, China.
和多醇基物质 (PFAS) 的暴露与甲状腺激素 (TH) 和脂质水平的变化有关. 这些对TH和胆固醇的影响似乎是独立的,它们之间没有干扰.
科学领域:
- 环境健康 环境健康
- 内分泌学 在内分泌学.
- 毒理学 毒理学 毒理学
背景情况:
- 和多基基物质 (PFAS) 是广泛检测到的环境污染物.
- 之前的研究表明,PFAS暴露与改变的甲状腺激素 (TH) 和脂质配置文件之间存在关联.
- PFAS暴露的这两种影响之间的潜在相互作用仍然不清楚.
研究的目的:
- 调查PFAS暴露对甲状腺激素和脂质水平的影响是否相互干扰.
- 分析PFAS,TH障碍和脂质水平在美国成年人群中的独立和联合影响.
主要方法:
- 在美国国家健康和营养检查调查 (NHANES; 2007-2012) 中分析了3954名成年人的数据.
- 使用权重定量总和 (WQS) 回归来评估PFAS混合物对TH障碍和胆固醇水平的整体影响.
- 针对包括人口统计,吸烟和酒精消费在内的潜在混因素进行了统计调整.
主要成果:
- 暴露于PFAS混合物与增加TH障碍风险,较高的HDL胆固醇和较高的总胆固醇显著相关.
- TH 疾病与较高的 HDL 胆固醇相关,但与总胆固醇无关.
- 在调整为TH障碍时,PFAS混合物对HDL和总胆固醇的影响基本保持不变,表明独立性.
结论:
- PFAS暴露与甲状腺激素和脂质水平的不良影响有关.
- 观察到的PFAS对甲状腺激素和脂质配置文件的影响似乎是独立的过程,不会相互干扰.
- 性别被确定为PFAS混合物对HDL胆固醇影响的修饰因素.
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