选择类型和数量通过干涂层提高流动性:基于接触力学的预测方法
Kuriakose T Kunnath1, Siddharth Tripathi1, Sangah S Kim1
1New Jersey Center for Engineered Particulates, New Jersey Institute of Technology, Newark, NJ, 07102, USA.
Pharmaceutical research
|July 19, 2023
概括
用二氧化干覆盖制药粉末显著提高了流动性,特别是在50%的表面覆盖面积 (SAC) 时. 邦德数,不仅仅是颗粒大小,准确地预测粉末处理后的流动性.
科学领域:
- 制药科学 制药科学
- 材料科学 材料科学 材料科学
- 粉末技术技术 粉末技术
背景情况:
- 粉末的流动性对于制药制造过程至关重要.
- 预测粉末流量的现有方法存在局限性.
- 使用二氧化干涂层是一种改善粉末性能的潜在策略.
研究的目的:
- 评估类型和数量对19种不同的制药粉末流动性的影响.
- 用Bond数和机械粒子接触模型来评估粉末流的可预测性.
主要方法:
- 粉末的特性,包括粒子大小,形状,密度,表面能量和形态.
- 在不同表面积覆盖率 (SAC) 上使用疏水性 (R972P) 或疏水性 (A200) 纳米二氧化对粉末进行干涂.
- 粉末流动性 (FFC) 和流量可预测性的评估,使用颗粒大小和债券号.
主要成果:
- 两种类型的二氧化的最佳流量增强达到50%的SAC,改善了至少一类的流量.
- 疏水性R972P二氧化的性能略高于疏水性A200. 的性能.
- 在流量函数系数 (FFC) 和债券数之间观察到一个权力法关系.
结论:
- 使用的干涂层,特别是50%的SAC,显著提高了凝聚性制药粉末的流动性.
- 使用多度粒子接触模型计算的Bond数,与单独的粒子大小相比,提供了优越的流动性预测.
- 该研究强调了考虑颗粒特征和二氧化特性对于有效增强粉末流动的重要性.
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