怀孕妇女的肠道微生物群的变化模式分隔二十年 - 一项观察性研究
Samuli Rautava1,2, Marta Selma-Royo3, Teo Oksanen1,4
1Department of Clinical Sciences, Faculty of Medicine, University of Turku, Turku, Finland.
Gut microbes
|July 19, 2023
概括
怀孕妇女的肠道微生物群多样性在过去20年里有所下降,反映了环境生物多样性丧失. 这种转变与肥胖风险增加和改变短链脂肪酸特征相关.
科学领域:
- 微生物组研究的研究.
- 人类健康 人类健康 人类健康
- 环境科学环境科学
背景情况:
- 近几十年来,环境生物多样性有所减少.
- 肠道微生物群多样性的并行下降可能会导致肥胖流行.
研究的目的:
- 研究20年来孕妇肠道微生物群组成和功能的时间变化.
- 为了在不同时间点比较正常体重和超重体重的孕妇之间的微生物群概况.
主要方法:
- 来自124名孕妇的便样本的16S rRNA基因测序 (1997年,2007年,2017年).
- 便短链脂肪酸 (SCFA) 概况的气色谱-质谱学 (GC-MS) 分析.
- 包括PERMANOVA在内的统计分析用于微生物群组成差异.
主要成果:
- 多年来 (1997年,2007年,2017年) 观察到肠道微生物群概况的显著差异.
- 与2007年和2017年相比,1997年的孕妇显示出更高的微生物群丰富性,多样性和便SCFA度.
- 在1997年,正常体重和超重妇女之间存在明显的微生物群差异,但在以后的几年中没有.
结论:
- 肠道微生物群的丰富性和多样性在过去二十年中一直在下降,与环境生物多样性下降并行.
- 随着时间的推移,孕妇的肠道微生物群组成已经转向与超重个体相关的特征.
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