生物化学标记物的协会与巴基斯坦的COVID-19严重性
Rashid Iqbal1, Muhammad Aamir Khan Niazi1, Muhammad Usman Shabbir1
1Department of Medical Technology, Shifa College of Medical Technology, Shifa Tameer-e-Millat University, Islamabad, Pakistan.
JPMA. The Journal of the Pakistan Medical Association
|July 20, 2023
概括
这项研究发现,老年,慢性病,癌症,呼吸短促和胸痛与严重的冠状病毒疾病-2019 (COVID-19) 有关. 生物化学标记物也有效监测COVID-19的进展.
科学领域:
- 医学研究 医学研究
- 传染性疾病 传染性疾病
- 临床生物化学 临床生物化学
背景情况:
- 新型冠状病毒疾病-2019 (COVID-19) 构成了重大的全球健康挑战.
- 了解患者的人口,临床和生物化学概况对于管理疾病至关重要.
- 之前的研究已经探讨了各种各样的方面,但需要对特定人群中的这些因素进行全面评估.
研究的目的:
- 评估COVID-19患者的人口统计,生化标志物和临床特征.
- 确定与COVID-19严重程度相关的因素.
- 评估生物化学标记物在监测疾病进展中的有用性.
主要方法:
- 从2021年10月到2022年3月,在巴基斯坦的两家医院进行了一项回顾性横截面研究.
- 分析了通过RT-PCR诊断出COVID-19的431名患者的数据.
- 根据世卫组织的标准,患者被分为非严重,严重和关键组;收集了人口统计,临床和实验室数据.
主要成果:
- 该研究包括431名患者 (21.1%男性,78.9%女性),平均年龄为60.75岁.
- 高血压 (71.2%) 和糖尿病 (57.8%) 是常见的并发症;发烧 (81.9%),呼吸困难 (78.7%) 和咳 (70.1%) 是普遍的症状.
- 高龄,慢性病,癌症,呼吸短促,胸痛,以及各种生物化学标记物 (胆红素,ALT,尿素,肌素,白细胞计数,D-Dimer,费里丁,LDH,IL-6) 的水平升高与COVID-19严重程度的增加显著相关.
结论:
- 生物化学标记是监测2019年新冠肺炎疾病进展的绝佳工具.
- 识别严重程度的临床和生化指标可以帮助患者管理和风险分层.
- 进一步的研究可以探索针对这些标记物的治疗干预措施.
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